ENSMUSG00000011751


Mus musculus

Features
Gene ID: ENSMUSG00000011751
  
Biological name :Sptbn4
  
Synonyms : spectrin beta, non-erythrocytic 4 / Sptbn4
  
Possible biological names infered from orthology : Q9H254
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 27356383
Gene end: 27447686
  
Corresponding Affymetrix probe sets: 10561266 (MoGene1.0st)   1425116_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104001
Ensembl peptide - ENSMUSP00000104000
Ensembl peptide - ENSMUSP00000120738
Ensembl peptide - ENSMUSP00000132807
Ensembl peptide - ENSMUSP00000011895
Ensembl peptide - ENSMUSP00000103999
NCBI entrez gene - 80297     See in Manteia.
MGI - MGI:1890574
RefSeq - XM_006540437
RefSeq - NM_001199234
RefSeq - NM_001199235
RefSeq - NM_001199236
RefSeq - NM_032610
RefSeq - XM_006540436
RefSeq Peptide - NP_001186164
RefSeq Peptide - NP_001186165
RefSeq Peptide - NP_115999
RefSeq Peptide - NP_001186163
swissprot - Q91ZE6
swissprot - E9PZC2
swissprot - E9PX29
swissprot - D3YWH8
Ensembl - ENSMUSG00000011751
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-262h23.4ENSDARG00000111942Danio rerio
 si:dkey-27p18.5ENSDARG00000068624Danio rerio
 SPTBN4ENSDARG00000092624Danio rerio
 Q9H254ENSG00000160460Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*ENSMUSG0000002031547
Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*ENSMUSG0000006788944
Sptb / spectrin beta, erythrocytic / P11277*ENSMUSG0000002106144
P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*ENSMUSG0000005773818
Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*ENSMUSG0000002653217
Actn1 / Q7TPR4 / Mus musculus actinin, alpha 1 (Actn1), transcript variant 2, mRNA. / P12814* / actinin alpha 1*ENSMUSG0000001514310
Actn3 / O88990 / Alpha-actinin-3 / Q08043* / actinin alpha 3 (gene/pseudogene)*ENSMUSG0000000645710
Actn4 / P57780 / Alpha-actinin-4 / O43707* / actinin alpha 4*ENSMUSG0000005480810
Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*ENSMUSG0000005237410


Protein motifs (from Interpro)
Interpro ID Name
 IPR001589  Actinin-type actin-binding domain, conserved site
 IPR001605  Pleckstrin homology domain, spectrin-type
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR011993  PH-like domain superfamily
 IPR016343  Spectrin, beta subunit
 IPR018159  Spectrin/alpha-actinin
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002028 regulation of sodium ion transport IMP
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010459 negative regulation of heart rate IMP
 biological_processGO:0019226 transmission of nerve impulse IMP
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IMP
 biological_processGO:0022414 reproductive process IMP
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0033135 regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0045162 clustering of voltage-gated sodium channels IMP
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0061337 cardiac conduction IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0008091 spectrin ISS
 cellular_componentGO:0014704 intercalated disc IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0016605 PML body ISS
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0033268 node of Ranvier IDA
 cellular_componentGO:0033270 paranode region of axon IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043194 axon initial segment IDA
 cellular_componentGO:0043203 axon hillock IDA
 cellular_componentGO:0070852 cell body fiber IDA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0019902 phosphatase binding ISO
 molecular_functionGO:0030506 ankyrin binding IDA
 molecular_functionGO:0030507 spectrin binding IDA


Pathways (from Reactome)
Pathway description
NCAM signaling for neurite out-growth
Interaction between L1 and Ankyrins
RAF/MAP kinase cascade
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Sptbn4qv-lnd/Sptbn4qv-lnd
Genetic Background: B6.B10-Sptbn4qv-lnd

Allelic Composition: Sptbn4qv-9J/Sptbn4qv-9J
Genetic Background: involves: BALB/cByJ * C57BL/6J

Allelic Composition: Sptbn4qv-3J/Sptbn4qv-3J
Genetic Background: C57BL/6J-Sptbnqv-3J/J

Allelic Composition: Sptbn4tm1Mkom/Sptbn4tm1Mkom
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: 129S4/SvJaeSor-Spnb4Gt(ROSABetageo)62Sor

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: B6.129S4-Sptbn4Gt(ROSABetageo)62Sor/Mmucd

Allelic Composition: Sptbn4qv-8J/Sptbn4qv-8J
Genetic Background: C57BL/6J-Sptbn4qv-8J/J

Allelic Composition: Sptbn4qv-10J/Sptbn4qv-10J
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Sptbn4qv-J/Sptbn4qv-J
Genetic Background: C3FeB6 A/Aw-J-Sptbn4qv-J/J

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sptbn4qv-lnd/Sptbn4qv-lnd
Genetic Background: B6.B10-Sptbn4qv-lnd

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sptbn4tm1Mkom/Sptbn4tm1Mkom
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Chd7Flo/Chd7+
Genetic Background: involves: C3HeB/FeJ

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0001377 abnormal copulation "reduced or absent attempt of sexual contact between a male and a receptive female " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: 129S4/SvJaeSor-Spnb4Gt(ROSABetageo)62Sor

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: B6.129S4-Sptbn4Gt(ROSABetageo)62Sor/Mmucd

Allelic Composition: Sptbn4qv-10J/Sptbn4qv-10J
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Sptbn4qv-lnd/Sptbn4qv-lnd
Genetic Background: B6.B10-Sptbn4qv-lnd

Allelic Composition: Sptbn4qv-10J/Sptbn4qv-10J
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Sptbn4qv-9J/Sptbn4qv-9J
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Map3k7Gt(XB444)Byg/Map3k7Gt(XB444)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: 129S4/SvJaeSor-Spnb4Gt(ROSABetageo)62Sor

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: B6.129S4-Sptbn4Gt(ROSABetageo)62Sor/Mmucd

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Sptbn4qv-10J/Sptbn4qv-10J
Genetic Background: involves: BALB/cJ * C57BL/6J

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Sptbn4qv-lnd/Sptbn4qv-lnd
Genetic Background: B6.B10-Sptbn4qv-lnd

Allelic Composition: Sptbn4qv-10J/Sptbn4qv-10J
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Sptbn4qv-10J/Sptbn4qv-10J
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Sptbn4qv-9J/Sptbn4qv-9J
Genetic Background: involves: BALB/cByJ * C57BL/6J

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0003225 axonal dystrophy "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission]
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Allelic Composition: Sptbn4qv-lnd/Sptbn4qv-lnd
Genetic Background: B6.B10-Sptbn4qv-lnd

 MP:0003314 dysmetria "an inability to control the range of motion, typified by under- or over-shooting the intended position with the hand, arm, leg or eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

 MP:0004631 abnormal auditory cortex morphology "any structural abnormality in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body, a thalamic cell group receiving auditory input from the cochlear nuclei in the rhombencephalon and is responsible for processing of auditory (sound) information" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Sptbn4qv-3J/Sptbn4qv-3J
Genetic Background: C57BL/6J-Sptbnqv-3J/J

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: involves: CBA/Gr

Allelic Composition: Sptbn4qv-2J/Sptbn4qv-2J
Genetic Background: CXB6/By Sptbn4qv-2J

 MP:0004813 absent linear vestibular evoked potential "absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

Allelic Composition: Sptbn4qv-3J/Sptbn4qv-3J
Genetic Background: C57BL/6J-Sptbnqv-3J/J

 MP:0004814 reduced linear vestibular evoked potential "reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal s head)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2ho-4J/Grid2ho-4J
Genetic Background: DBA/2J-Grid2ho-4J/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sptbn4tm1Mkom/Sptbn4tm1Mkom
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: 129S4/SvJaeSor-Spnb4Gt(ROSABetageo)62Sor

Allelic Composition: Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic Background: B6.129S4-Sptbn4Gt(ROSABetageo)62Sor/Mmucd

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

Allelic Composition: Sptbn4qv-4J/Sptbn4qv-4J
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

Allelic Composition: Sptbn4qv-4J/Sptbn4qv-4J
Genetic Background: involves: C57BL/6J * CBA/CaJ * DBA/2J

Allelic Composition: Sptbn4qv-10J/Sptbn4qv-10J
Genetic Background: involves: BALB/cJ * C57BL/6J

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000032826 Ank2 / Q8C8R3 / Ankyrin-2 / Q01484*  / reaction / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / complex
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / complex
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / complex
 ENSMUSG00000031543 Ank1 / Q02357 / Ankyrin-1 / P16157*  / reaction / complex
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / complex
 ENSMUSG00000027303 Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*  / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr