ENSMUSG00000027303


Mus musculus

Features
Gene ID: ENSMUSG00000027303
  
Biological name :Ptpra
  
Synonyms : P18052 / protein tyrosine phosphatase, receptor type, A / Ptpra
  
Possible biological names infered from orthology : P18433
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 130450278
Gene end: 130556124
  
Corresponding Affymetrix probe sets: 10476163 (MoGene1.0st)   1425340_a_at (Mouse Genome 430 2.0 Array)   1447467_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028769
Ensembl peptide - ENSMUSP00000076533
Ensembl peptide - ENSMUSP00000155099
NCBI entrez gene - 19262     See in Manteia.
MGI - MGI:97808
RefSeq - XM_006498990
RefSeq - NM_001163688
RefSeq - NM_008980
RefSeq - XM_006498989
RefSeq Peptide - NP_001157160
RefSeq Peptide - NP_033006
swissprot - P18052
swissprot - Q91V35
Ensembl - ENSMUSG00000027303
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpraENSDARG00000001769Danio rerio
 PTPRAENSGALG00000015995Gallus gallus
 PTPRAENSG00000132670Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpre / P49446 / Receptor-type tyrosine-protein phosphatase epsilon / P23469* / protein tyrosine phosphatase, receptor type E*ENSMUSG0000004183656
Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*ENSMUSG0000003329542
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323641
Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*ENSMUSG0000002839939
Ptprc / protein tyrosine phosphatase, receptor type, CENSMUSG0000002639532
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327831
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988931
Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T / O14522* / protein tyrosine phosphatase, receptor type T*ENSMUSG0000005314130
B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*ENSMUSG0000006874829
Ptpru / B1AUH1 / protein tyrosine phosphatase, receptor type, U / Q92729*ENSMUSG0000002890928
Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2 / P23470* / protein tyrosine phosphatase, receptor type G*ENSMUSG0000002174528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR016336  Receptor tyrosine-protein phosphatase, alpha/epsilon-type
 IPR027262  Receptor tyrosine-protein phosphatase alpha
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0002068 abnormal parental behavior "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1rtm1Arge/Igf1r+,Igf2rtm1Arge/Igf2rtm1Arge
Genetic Background: involves: 129/Sv * 129S/SvEv

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Chl1tm1Mtg/Chl1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000026532 Spta1 / P08032 / Spectrin alpha chain, erythrocytic 1 / P02549* / spectrin alpha, erythrocytic 1*  / complex
 ENSMUSG00000011751 Sptbn4 / spectrin beta, non-erythrocytic 4 / Q9H254*  / complex
 ENSMUSG00000057738 P16546 / Sptan1 / Spectrin alpha chain, non-erythrocytic 1 / Q13813* / spectrin alpha, non-erythrocytic 1*  / complex
 ENSMUSG00000020315 Q62261 / Sptbn1 / Spectrin beta chain, non-erythrocytic 1 / Q01082* / spectrin beta, non-erythrocytic 1*  / complex
 ENSMUSG00000021061 Sptb / spectrin beta, erythrocytic / P11277*  / complex
 ENSMUSG00000067889 Sptbn2 / spectrin beta, non-erythrocytic 2 / O15020*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex






 

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