ENSMUSG00000028909


Mus musculus

Features
Gene ID: ENSMUSG00000028909
  
Biological name :Ptpru
  
Synonyms : B1AUH1 / protein tyrosine phosphatase, receptor type, U / Ptpru
  
Possible biological names infered from orthology : Q92729
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 131768457
Gene end: 131838288
  
Corresponding Affymetrix probe sets: 10516789 (MoGene1.0st)   1416674_at (Mouse Genome 430 2.0 Array)   1446638_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030741
Ensembl peptide - ENSMUSP00000095472
Ensembl peptide - ENSMUSP00000101607
NCBI entrez gene - 19273     See in Manteia.
MGI - MGI:1321151
RefSeq - XM_017320082
RefSeq - NM_001083119
RefSeq - NM_011214
RefSeq - XM_011250213
RefSeq - XM_011250214
RefSeq - XM_011250215
RefSeq - XM_011250216
RefSeq - XM_006538666
RefSeq - XM_006538667
RefSeq - XM_006538668
RefSeq - XM_006538670
RefSeq - XM_006538672
RefSeq - XM_006538673
RefSeq - XM_006538674
RefSeq - XM_011250210
RefSeq - XM_011250211
RefSeq - XM_011250212
RefSeq Peptide - NP_001076588
RefSeq Peptide - NP_035344
swissprot - Q3V360
swissprot - B1AUH1
Ensembl - ENSMUSG00000028909
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpruaENSDARG00000092638Danio rerio
 ptprubENSDARG00000101081Danio rerio
 PTPRUENSGALG00000031440Gallus gallus
 PTPRUENSG00000060656Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988959
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327853
Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T / O14522* / protein tyrosine phosphatase, receptor type T*ENSMUSG0000005314151
Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*ENSMUSG0000003329526
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323626
Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*ENSMUSG0000002839924
B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*ENSMUSG0000006874820
Ptprc / protein tyrosine phosphatase, receptor type, CENSMUSG0000002639518
Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2 / P23470* / protein tyrosine phosphatase, receptor type G*ENSMUSG0000002174518
Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*ENSMUSG0000002730316
Ptpre / P49446 / Receptor-type tyrosine-protein phosphatase epsilon / P23469* / protein tyrosine phosphatase, receptor type E*ENSMUSG0000004183615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000998  MAM domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0034109 homotypic cell-cell adhesion IDA
 biological_processGO:0034394 protein localization to cell surface IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction






 

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