ENSMUSG00000053141


Mus musculus

Features
Gene ID: ENSMUSG00000053141
  
Biological name :Ptprt
  
Synonyms : Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T
  
Possible biological names infered from orthology : O14522 / protein tyrosine phosphatase, receptor type T
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H2
Gene start: 161521990
Gene end: 162661147
  
Corresponding Affymetrix probe sets: 10489305 (MoGene1.0st)   1421238_a_at (Mouse Genome 430 2.0 Array)   1439725_at (Mouse Genome 430 2.0 Array)   1450174_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105067
Ensembl peptide - ENSMUSP00000105068
Ensembl peptide - ENSMUSP00000105069
Ensembl peptide - ENSMUSP00000105071
NCBI entrez gene - 19281     See in Manteia.
MGI - MGI:1321152
RefSeq - XM_017316600
RefSeq - NM_001291149
RefSeq - NM_001291150
RefSeq - NM_001291151
RefSeq - NM_021464
RefSeq - XM_017316592
RefSeq - XM_017316593
RefSeq - XM_017316594
RefSeq - XM_017316595
RefSeq - XM_017316597
RefSeq - XM_017316598
RefSeq - XM_011239384
RefSeq - XM_011239385
RefSeq - XM_017316586
RefSeq - XM_017316587
RefSeq - XM_017316590
RefSeq Peptide - NP_001278078
RefSeq Peptide - NP_001278079
RefSeq Peptide - NP_001278080
RefSeq Peptide - NP_067439
swissprot - Q99M80
swissprot - B1AQN2
Ensembl - ENSMUSG00000053141
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprtENSDARG00000074781Danio rerio
 ptprtENSDARG00000097572Danio rerio
 PTPRTENSGALG00000037889Gallus gallus
 PTPRTENSG00000196090Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327865
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988957
Ptpru / B1AUH1 / protein tyrosine phosphatase, receptor type, U / Q92729*ENSMUSG0000002890951
Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*ENSMUSG0000003329526
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323626
Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*ENSMUSG0000002839925
B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*ENSMUSG0000006874822
Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2 / P23470* / protein tyrosine phosphatase, receptor type G*ENSMUSG0000002174519
Ptprc / protein tyrosine phosphatase, receptor type, CENSMUSG0000002639519
Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*ENSMUSG0000002730317
Ptpre / P49446 / Receptor-type tyrosine-protein phosphatase epsilon / P23469* / protein tyrosine phosphatase, receptor type E*ENSMUSG0000004183617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000998  MAM domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation ISO
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISO
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISO
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016790 thiolester hydrolase activity IDA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0045294 alpha-catenin binding ISO
 molecular_functionGO:0045295 gamma-catenin binding ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0051393 alpha-actinin binding IDA
 molecular_functionGO:0070097 delta-catenin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
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Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10ratm1.2Jack/Il10ratm1.2Jack
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex






 

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