ENSMUSG00000026395


Mus musculus

Features
Gene ID: ENSMUSG00000026395
  
Biological name :Ptprc
  
Synonyms : protein tyrosine phosphatase, receptor type, C / Ptprc
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 138062861
Gene end: 138175708
  
Corresponding Affymetrix probe sets: 10358224 (MoGene1.0st)   1422124_a_at (Mouse Genome 430 2.0 Array)   1440165_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138275
Ensembl peptide - ENSMUSP00000138800
Ensembl peptide - ENSMUSP00000141524
Ensembl peptide - ENSMUSP00000142052
Ensembl peptide - ENSMUSP00000138350
NCBI entrez gene - 19264     See in Manteia.
MGI - MGI:97810
RefSeq - XM_006529262
RefSeq - NM_001111316
RefSeq - NM_001268286
RefSeq - NM_011210
RefSeq - XM_006529257
RefSeq - XM_006529258
RefSeq - XM_006529259
RefSeq - XM_006529260
RefSeq - XM_006529261
RefSeq Peptide - NP_001255215
RefSeq Peptide - NP_035340
RefSeq Peptide - NP_001104786
swissprot - A0A0A6YWF2
swissprot - A0A0A6YXM4
swissprot - S4R1M0
swissprot - S4R1S4
swissprot - S4R2V1
Ensembl - ENSMUSG00000026395
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprcENSDARG00000071437Danio rerio
 PTPRCENSGALG00000002192Gallus gallus
 PTPRCENSG00000081237Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323626
Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*ENSMUSG0000003329526
Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*ENSMUSG0000002839924
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327822
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988922
Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T / O14522* / protein tyrosine phosphatase, receptor type T*ENSMUSG0000005314122
Ptpre / P49446 / Receptor-type tyrosine-protein phosphatase epsilon / P23469* / protein tyrosine phosphatase, receptor type E*ENSMUSG0000004183620
Ptpru / B1AUH1 / protein tyrosine phosphatase, receptor type, U / Q92729*ENSMUSG0000002890920
Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*ENSMUSG0000002730320
B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*ENSMUSG0000006874820
Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2 / P23470* / protein tyrosine phosphatase, receptor type G*ENSMUSG0000002174520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR016335  Receptor-type tyrosine-protein phosphatase C
 IPR024739  Protein tyrosine phosphatase, receptor type, N-terminal
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Samd9ltm1Homy/Samd9ltm1Homy
Genetic Background: B6N.129P2-Samd9ltm1Homy

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnna1Gt(fVET3A)Hiir/Ctnna1Gt(fVET3A)Hiir
Genetic Background: involves: C3H * C57BL/6

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnna1Gt(fVET3A)Hiir/Ctnna1Gt(fVET3A)Hiir
Genetic Background: involves: C3H * C57BL/6

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

Allelic Composition: Ptprcltng/Ptprcltng
Genetic Background: C57BL/6-Ptprcltng

Allelic Composition: Csktm1Sor/Csk+,Ptprcltng/Ptprcltng
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptprcltng/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Csktm1Sor/Csk+,Ptprcltng/Ptprctm1Mak
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: ApcMin/Apc+,Thbs1tm1Hyn/Thbs1tm1Hyn
Genetic Background: involves: C57BL/6J

Allelic Composition: Ptprctm1Holm/Ptprctm1Holm,Tg(Lck*F505)3073Rmp/?
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

Allelic Composition: Ptprctm1Weis/Ptprc+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

Allelic Composition: Ptprcltng/Ptprcltng
Genetic Background: C57BL/6-Ptprcltng

Allelic Composition: Ptprcltng/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Csktm1Sor/Csk+,Ptprcltng/Ptprctm1Mak
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: B6.Cg-Ptprctm1Mak

Allelic Composition: Dhx9Tn(pb-Act-RFP)1.071225026-HRAZhu/Dhx9+,Igs12tm1Zhu/Igs12tm1Zhu,Ptprca/Ptprcb,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ * SJL/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnna1Gt(fVET3A)Hiir/Ctnna1Gt(fVET3A)Hiir
Genetic Background: involves: C3H * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Ptprctm1Weis/Ptprc+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Weis/Ptprc+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004917 abnormal T cell selection "any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation" [GO:0045058]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

Allelic Composition: Ptprcstrm/Ptprcstrm
Genetic Background: C57BL/6JAnu-Ptprcstrm/Apb

Allelic Composition: Ptprcnim/Ptprcnim
Genetic Background: C57BL/6JAnu-Ptprcnim

Allelic Composition: Ptprcm3Btlr/Ptprcm3Btlr
Genetic Background: C57BL/6J-Ptprcm3Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptprcstrm/Ptprcstrm
Genetic Background: C57BL/6JAnu-Ptprcstrm/Apb

Allelic Composition: Ptprcnim/Ptprcnim
Genetic Background: C57BL/6JAnu-Ptprcnim

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: B6.Cg-Ptprctm1Mak

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptprcm1Smv/Ptprcm1Smv
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

Allelic Composition: Ptprcltng/Ptprcltng
Genetic Background: C57BL/6-Ptprcltng

Allelic Composition: Ptprcltng/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptprctm1Weis/Ptprc+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Ptprcm1Smv/Ptprcm1Smv
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: B6.Cg-Ptprctm1Mak

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0008048 abnormal memory T cell number "deviation from the normal number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm3(APOE*4)Mae/Apoetm3(APOE*4)Mae,Ldlrtm1(LDLR)Mae/Ldlr+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

Allelic Composition: Ptprcltng/Ptprcltng
Genetic Background: C57BL/6-Ptprcltng

Allelic Composition: Ptprcltng/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

Allelic Composition: Ptprcltng/Ptprctm1Mak,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129/Sv * BALB/c * C57BL/6

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprcm1Smv/Ptprcm1Smv
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsta4tm1Pzim/Gsta4+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Ptprctm1Tyb/Ptprctm1Tyb
Genetic Background: C.129S2-Ptprctm1Tyb

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ptprcm3Btlr/Ptprcm3Btlr
Genetic Background: C57BL/6J-Ptprcm3Btlr

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprcm1Smv/Ptprcm1Smv
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

Allelic Composition: Ptprcm3Btlr/Ptprcm3Btlr
Genetic Background: C57BL/6J-Ptprcm3Btlr

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

Allelic Composition: Ptprcm3Btlr/Ptprcm3Btlr
Genetic Background: C57BL/6J-Ptprcm3Btlr

 MP:0008172 abnormal follicular B cell morphology "any structural anomaly of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * BALB/cJ * C57BL/6

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0008188 abnormal transitional stage B cell morphology "any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0008191 abnormal follicular B cell physiology "abnormal function of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

Allelic Composition: Ptprcm3Btlr/Ptprcm3Btlr
Genetic Background: C57BL/6J-Ptprcm3Btlr

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

Allelic Composition: Ptprcm2Btlr/Ptprcm2Btlr
Genetic Background: C57BL/6J-Ptprcm2Btlr

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak,Ptprjtm1.2Weis/Ptprjtm1.2Weis
Genetic Background: B6.Cg-Ptprctm1Mak Ptprjtm1.2Weis

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptpn22tm2Achn/Ptpn22tm2Achn,Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.Cg-Ptprctm1Weis Ptpn22tm2Achn

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: B6.129X1-Ptprctm1Weis

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Irf1tm1Mak/Irf1tm1Mak,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0008351 decreased gamma-delta intraepithelial T cell number "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: B6.Cg-Ptprctm1Mak

 MP:0008400 abnormal CD4-positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD4-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: B6.Cg-Ptprctm1Mak

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprctm1Weis/Ptprc+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008524 increased plasmacytoid dendritic cell number "greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]
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Allelic Composition: Ptprctm1Weis/Ptprctm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

 MP:0008729 decreased memory B cell number "reduced number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprcm2Btlr/Ptprcm2Btlr
Genetic Background: C57BL/6J-Ptprcm2Btlr

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0008894 abnormal intraepithelial T cell morphology "any structural anomaly of a T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: B6.Cg-Ptprctm1Mak

 MP:0008895 abnormal intraepithelial T cell number "reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: B6.Cg-Ptprctm1Mak

 MP:0009785 altered susceptibility to infection induced morbidity/mortality "differences from the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Spata18tm1.2Hifa/Spata18+
Genetic Background: involves: C57BL/6J

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/OlaHsd

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Ptprcm1Smv/Ptprcm1Smv
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Ptprcm1Smv/Ptprcm1Smv
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR

Allelic Composition: Ptprctm1Mak/Ptprctm1Mak
Genetic Background: B6.Cg-Ptprctm1Mak

Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0010836 decreased CD4-positive, alpha-beta memory T cell number "reduced number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
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Allelic Composition: Ptprcm2Btlr/Ptprcm2Btlr
Genetic Background: C57BL/6J-Ptprcm2Btlr

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Ptprcm2Btlr/Ptprcm2Btlr
Genetic Background: C57BL/6J-Ptprcm2Btlr

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Gnastm4Lsw/Gnas+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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