ENSMUSG00000021745


Mus musculus

Features
Gene ID: ENSMUSG00000021745
  
Biological name :Ptprg
  
Synonyms : Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2
  
Possible biological names infered from orthology : P23470 / protein tyrosine phosphatase, receptor type G
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A1
Gene start: 11553532
Gene end: 12242041
  
Corresponding Affymetrix probe sets: 10412667 (MoGene1.0st)   1429691_at (Mouse Genome 430 2.0 Array)   1434360_s_at (Mouse Genome 430 2.0 Array)   1450122_at (Mouse Genome 430 2.0 Array)   1456070_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022264
Ensembl peptide - ENSMUSP00000152991
Ensembl peptide - ENSMUSP00000121427
Ensembl peptide - ENSMUSP00000121268
Ensembl peptide - ENSMUSP00000113679
NCBI entrez gene - 19270     See in Manteia.
MGI - MGI:97814
RefSeq - XM_006517957
RefSeq - NM_008981
RefSeq - XM_006517956
RefSeq Peptide - NP_001334522
RefSeq Peptide - NP_033007
swissprot - E9Q6E7
swissprot - F8VQD7
swissprot - A0A286YCH6
swissprot - D3Z2S6
swissprot - D6RD11
Ensembl - ENSMUSG00000021745
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ca16bENSDARG00000060123Danio rerio
 ptprgaENSDARG00000045006Danio rerio
 PTPRGENSGALG00000007177Gallus gallus
 PTPRGENSG00000144724Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*ENSMUSG0000006874848
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323624
Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*ENSMUSG0000003329524
Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*ENSMUSG0000002839923
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988920
Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T / O14522* / protein tyrosine phosphatase, receptor type T*ENSMUSG0000005314119
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327819
Ptpru / B1AUH1 / protein tyrosine phosphatase, receptor type, U / Q92729*ENSMUSG0000002890918
Ptprc / protein tyrosine phosphatase, receptor type, CENSMUSG0000002639518
Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*ENSMUSG0000002730316
Ptpre / P49446 / Receptor-type tyrosine-protein phosphatase epsilon / P23469* / protein tyrosine phosphatase, receptor type E*ENSMUSG0000004183615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001148  Alpha carbonic anhydrase domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036398  Alpha carbonic anhydrase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IEA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Dlg1Gt(RRN196)Byg/Dlg1Gt(RRN196)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: T/t6
Genetic Background: Not Specified

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: T/t6
Genetic Background: Not Specified

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: T/t6
Genetic Background: Not Specified

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: T/t6
Genetic Background: Not Specified

 MP:0002738 hyperresponsive to tactile stimuli "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: T/t6
Genetic Background: Not Specified

 MP:0003360 depression-related behavior 
Show

Allelic Composition: Dlg1Gt(RRN196)Byg/Dlg1Gt(RRN196)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Ptprgtm1.1Lex/Ptprgtm1.1Lex
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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