ENSMUSG00000041836


Mus musculus

Features
Gene ID: ENSMUSG00000041836
  
Biological name :Ptpre
  
Synonyms : P49446 / Ptpre / Receptor-type tyrosine-protein phosphatase epsilon
  
Possible biological names infered from orthology : P23469 / protein tyrosine phosphatase, receptor type E
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 135537481
Gene end: 135686293
  
Corresponding Affymetrix probe sets: 10558410 (MoGene1.0st)   1418539_a_at (Mouse Genome 430 2.0 Array)   1418540_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147656
Ensembl peptide - ENSMUSP00000147613
Ensembl peptide - ENSMUSP00000147957
Ensembl peptide - ENSMUSP00000073616
Ensembl peptide - ENSMUSP00000147313
Ensembl peptide - ENSMUSP00000147524
NCBI entrez gene - 19267     See in Manteia.
MGI - MGI:97813
RefSeq - NM_001316678
RefSeq - NM_001316679
RefSeq - NM_001316680
RefSeq - NM_001316681
RefSeq - NM_011212
RefSeq Peptide - NP_035342
RefSeq Peptide - NP_001303608
RefSeq Peptide - NP_001303609
RefSeq Peptide - NP_001303610
RefSeq Peptide - NP_001303607
swissprot - P49446
swissprot - A0A1B0GRT6
swissprot - A0A1B0GRH2
Ensembl - ENSMUSG00000041836
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpreaENSDARG00000015891Danio rerio
 ptprebENSDARG00000021151Danio rerio
 PTPREENSGALG00000009823Gallus gallus
 PTPREENSG00000132334Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpra / P18052 / protein tyrosine phosphatase, receptor type, A / P18433*ENSMUSG0000002730365
Ptprs / B0V2N1 / Receptor-type tyrosine-protein phosphatase S / Q13332* / protein tyrosine phosphatase, receptor type S*ENSMUSG0000001323644
Ptprf / A2A8L5 / Receptor-type tyrosine-protein phosphatase F / P10586* / protein tyrosine phosphatase, receptor type F*ENSMUSG0000003329544
Ptprd / Q64487 / protein tyrosine phosphatase, receptor type, D / P23468*ENSMUSG0000002839942
Ptprc / protein tyrosine phosphatase, receptor type, CENSMUSG0000002639536
Ptprm / P28828 / protein tyrosine phosphatase, receptor type, M / P28827*ENSMUSG0000003327835
Ptprt / Q99M80 / Receptor-type tyrosine-protein phosphatase T / O14522* / protein tyrosine phosphatase, receptor type T*ENSMUSG0000005314134
Ptprk / P35822 / protein tyrosine phosphatase, receptor type, K / Q15262*ENSMUSG0000001988934
B9EKR1 / Ptprz1 / protein tyrosine phosphatase, receptor type Z, polypeptide 1 / P23471* / protein tyrosine phosphatase, receptor type Z1*ENSMUSG0000006874832
Ptprg / receptor-type tyrosine-protein phosphatase gamma isoform 2 / P23470* / protein tyrosine phosphatase, receptor type G*ENSMUSG0000002174531
Ptpru / B1AUH1 / protein tyrosine phosphatase, receptor type, U / Q92729*ENSMUSG0000002890930


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR016336  Receptor tyrosine-protein phosphatase, alpha/epsilon-type
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0033003 regulation of mast cell activation IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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