ENSMUSG00000031010


Mus musculus

Features
Gene ID: ENSMUSG00000031010
  
Biological name :Usp9x
  
Synonyms : ubiquitin specific peptidase 9, X chromosome / Usp9x
  
Possible biological names infered from orthology : Q93008 / ubiquitin specific peptidase 9, X-linked
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 13071498
Gene end: 13173328
  
Corresponding Affymetrix probe sets: 10598678 (MoGene1.0st)   1420922_at (Mouse Genome 430 2.0 Array)   1420923_at (Mouse Genome 430 2.0 Array)   1428193_at (Mouse Genome 430 2.0 Array)   1428194_at (Mouse Genome 430 2.0 Array)   1450037_at (Mouse Genome 430 2.0 Array)   1450038_s_at (Mouse Genome 430 2.0 Array)   1450039_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086716
Ensembl peptide - ENSMUSP00000129373
Ensembl peptide - ENSMUSP00000133948
Ensembl peptide - ENSMUSP00000134612
NCBI entrez gene - 22284     See in Manteia.
MGI - MGI:894681
RefSeq - XM_011247457
RefSeq - XM_006527589
RefSeq - XM_006527591
RefSeq - XM_011247454
RefSeq - XM_011247455
RefSeq - XM_011247456
RefSeq - NM_009481
RefSeq - XM_006527586
RefSeq - XM_006527587
RefSeq - XM_006527588
RefSeq Peptide - NP_033507
swissprot - G3UZS3
swissprot - G3UY52
swissprot - E9PWA9
swissprot - Q4FE56
Ensembl - ENSMUSG00000031010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP9XENSG00000124486Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp9y / ubiquitin specific peptidase 9, Y chromosome / O00507* / ubiquitin specific peptidase 9, Y-linked*ENSMUSG0000006904483
Usp24 / B1AY13 / ubiquitin specific peptidase 24 / Q9UPU5*ENSMUSG0000002851431
Usp34 / Q6ZQ93 / ubiquitin specific peptidase 34 / Q70CQ2*ENSMUSG0000005634220
Usp47 / Q8BY87 / ubiquitin specific peptidase 47 / Q96K76*ENSMUSG000000592637
Usp40 / Q8BWR4 / ubiquitin specific peptidase 40 / Q9NVE5*ENSMUSG000000055017
Usp48 / Q3V0C5 / ubiquitin specific peptidase 48 / Q86UV5*ENSMUSG000000434117
Usp7 / ubiquitin specific peptidase 7 / Q93009*ENSMUSG000000227107
Usp18 / Q9WTV6 / ubiquitin specific peptidase 18 / USP41* / Q9UMW8* / Q3LFD5* / ubiquitin specific peptidase 41*ENSMUSG000000301073


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:1901537 positive regulation of DNA demethylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030426 growth cone IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0070410 co-SMAD binding IEA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Ub-specific processing proteases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-15J/Oca2p-15J
Genetic Background: C57BL/6

 MP:0003752 oral papilloma "benign epithelial tumor of the oral cavity" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0009152 pancreatic intraepithelial neoplasia "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Y
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/0,Usp9xtm1Tuv/Usp9x+
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0012105 delayed gastrulation "late onset of the development and invagination of the embryonic germ layers" [MGI:anna]
Show

Allelic Composition: Il13tm3.1Anjm/Il13+,Il1rl1tm1Anjm/Il1rl1tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000020460 P62983 / Rps27a / ribosomal protein S27A / P62979*  / reaction
 ENSMUSG00000068240 P62984 / Gm11808 / predicted gene 11808 / UBA52* / P62987* / ubiquitin A-52 residue ribosomal protein fusion product 1*  / reaction
 ENSMUSG00000005069 Pex5 / O09012 / Peroxisomal targeting signal 1 receptor / P50542* / peroxisomal biogenesis factor 5*  / reaction / complex






 

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