ENSGALG00000012484


Gallus gallus

Features
Gene ID: ENSGALG00000012484
  
Biological name :RIF1
  
Synonyms : E1C2U2 / RIF1 / Telomere-associated protein RIF1
  
Possible biological names infered from orthology : Q5UIP0 / Q6PR54 / replication timing regulatory factor 1
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 35331804
Gene end: 35359923
  
Corresponding Affymetrix probe sets: Gga.5561.1.S1_at (Chicken Array)   GgaAffx.7921.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000036991
Ensembl peptide - ENSGALP00000056658
Ensembl peptide - ENSGALP00000045016
NCBI entrez gene - 424316     See in Manteia.
RefSeq - XM_015289867
RefSeq - XM_422162
swissprot - E1C2U2
swissprot - A0A1D5NXC1
Ensembl - ENSGALG00000012484
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rif1ENSDARG00000062650Danio rerio
 RIF1ENSG00000080345Homo sapiens
 Rif1ENSMUSG00000036202Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR022031  Telomere-associated protein Rif1, N-terminal
 IPR028566  Telomere-associated protein Rif1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006348 chromatin silencing at telomere IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0043247 telomere maintenance in response to DNA damage IEA
 biological_processGO:0045830 positive regulation of isotype switching ISS
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000042 negative regulation of double-strand break repair via homologous recombination ISS
 biological_processGO:2001034 positive regulation of double-strand break repair via nonhomologous end joining IMP
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0001939 female pronucleus IEA
 cellular_componentGO:0001940 male pronucleus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0035861 site of double-strand break ISS
 cellular_componentGO:0051233 spindle midzone IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / reaction / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction / complex
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / reaction / complex
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / reaction / complex
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction / complex
 ENSGALG00000042491 P62801 / Histone H4   / complex / reaction
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / complex / reaction
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / complex / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / complex / reaction
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / complex / reaction






 

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