ENSGALG00000011505


Gallus gallus

Features
Gene ID: ENSGALG00000011505
  
Biological name :MARK3
  
Synonyms : MARK3 / microtubule affinity regulating kinase 3
  
Possible biological names infered from orthology : MAP/microtubule affinity-regulating kinase 3 / P27448 / Q03141
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 50326246
Gene end: 50384620
  
Corresponding Affymetrix probe sets: Gga.17127.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000018736
NCBI entrez gene - 423480     See in Manteia.
RefSeq - XM_004936354
RefSeq - XM_004936355
RefSeq - XM_004936356
RefSeq - XM_004936357
RefSeq - XM_004936358
RefSeq - XM_004936359
RefSeq - XM_004936360
RefSeq - XM_004936361
RefSeq - XM_004936362
RefSeq - XM_004936363
RefSeq - XM_004936364
RefSeq - XM_004936365
RefSeq - XM_004936366
RefSeq - XM_004936367
RefSeq - XM_015287831
RefSeq - XM_421385
RefSeq - XM_001234618
swissprot - E1BRA3
Ensembl - ENSGALG00000011505
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mark3bENSDARG00000026630Danio rerio
 MARK3ENSG00000075413Homo sapiens
 Mark3ENSMUSG00000007411Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MARK1 / microtubule affinity regulating kinase 1 / Q8VHJ5* / Q9P0L2* / Serine/threonine-protein kinase MARK1 *ENSGALG0000000948375
SIK3 / SIK family kinase 3ENSGALG0000000714433
SIK1 / serine/threonine-protein kinase SIK2 / SIK1B* / Q60670* / P57059* / salt inducible kinase 1* / salt inducible kinase 1B (putative)* / Serine/threonine-protein kinase SIK1 *ENSGALG0000004198829
SIK2 / salt inducible kinase 2 / Q9H0K1*ENSGALG0000003687328
SNRK / SNF related kinase / Q8VDU5* / Q9NRH2* / Mus musculus SNF related kinase (Snrk), transcript variant 5, mRNA.*ENSGALG0000003992027
ENSGALG0000002604319
NIM1KZ / NIM1K* / Q8IY84* / Q8BHI9* / NIM1 serine/threonine protein kinase* / Serine/threonine-protein kinase NIM1 *ENSGALG0000001486119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR033628  Serine/threonine-protein kinase MARK3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction / complex
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr