ENSGALG00000012865


Gallus gallus

Features
Gene ID: ENSGALG00000012865
  
Biological name :BRAF
  
Synonyms : BRAF / Q04982 / Serine/threonine-protein kinase B-raf
  
Possible biological names infered from orthology : B-Raf proto-oncogene, serine/threonine kinase / P15056 / P28028
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 56983387
Gene end: 57058584
  
Corresponding Affymetrix probe sets: Gga.5033.1.S1_at (Chicken Array)   Gga.719.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051904
Ensembl peptide - ENSGALP00000020950
NCBI entrez gene - 396239     See in Manteia.
RefSeq - XM_015284541
RefSeq - NM_205302
RefSeq - XM_015284526
RefSeq - XM_015284532
RefSeq - XM_015284536
RefSeq Peptide - NP_990633
swissprot - F1P1L9
swissprot - A0A1D5PGI2
swissprot - Q04982
Ensembl - ENSGALG00000012865
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brafENSDARG00000017661Danio rerio
 BRAFENSG00000157764Homo sapiens
 BrafENSMUSG00000002413Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...ENSGALG0000000499846
KSR2 / kinase suppressor of ras 2 / Q6VAB6*ENSGALG0000002090522
KSR1 / kinase suppressor of ras 1 / Q61097* / Q8IVT5* / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA.*ENSGALG0000000568518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003116  Raf-like Ras-binding
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0002318 myeloid progenitor cell differentiation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0009968 negative regulation of signal transduction IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010764 negative regulation of fibroblast migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043367 CD4-positive, alpha-beta T cell differentiation IEA
 biological_processGO:0043368 positive T cell selection IEA
 biological_processGO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045580 regulation of T cell differentiation IEA
 biological_processGO:0046632 alpha-beta T cell differentiation IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048679 regulation of axon regeneration IEA
 biological_processGO:0048680 positive regulation of axon regeneration IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060323 head morphogenesis IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:2000301 negative regulation of synaptic vesicle exocytosis IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044297 cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Spry regulation of FGF signaling
RAF activation
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000007403 PEBP1 / phosphatidylethanolamine binding protein 1 / Pbp2* / P30086* / P70296*  / complex / reaction
 ENSGALG00000011505 MARK3 / microtubule affinity regulating kinase 3 / P27448* / Q03141* / MAP/microtubule affinity-regulating kinase 3 *  / reaction / complex
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / complex / reaction
 ENSGALG00000004143 YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...  / reaction / complex
 ENSGALG00000000055 Q5ZIP2 / LAMTOR3 / Ragulator complex protein LAMTOR3 / O88653* / Q9UHA4* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3*  / reaction / complex
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction / complex
 ENSGALG00000012865 BRAF / Q04982 / Serine/threonine-protein kinase B-raf / P15056* / P28028* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSGALG00000007687 MAP2K1 / mitogen-activated protein kinase kinase 1 / P31938* / Q02750* / Dual specificity mitogen-activated protein kinase kinase 1 *  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSGALG00000029881 LAMTOR2 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 / Q9JHS3* / Q9Y2Q5* / Ragulator complex protein LAMTOR2 *  / reaction / complex
 ENSGALG00000016906 SPRY2 / protein sprouty homolog 2 / O43597* / Q9QXV8* / sprouty RTK signaling antagonist 2*  / complex






 

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