ENSDARG00000028082


Danio rerio

Features
Gene ID: ENSDARG00000028082
  
Biological name :mapkapk5
  
Synonyms : mapkapk5 / mitogen-activated protein kinase-activated protein kinase 5
  
Possible biological names infered from orthology : Gm42878 / MAP kinase-activated protein kinase 5 / O54992 / Q8IW41
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 69553686
Gene end: 69571572
  
Corresponding Affymetrix probe sets: Dr.17304.1.A1_at (Zebrafish Array)   NM_001002336_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000113922
NCBI entrez gene - 436608     See in Manteia.
RefSeq - NM_001002336
RefSeq Peptide - NP_001002336
swissprot - A2BGS0
swissprot - Q6DHN7
ZFIN ID - ZDB-GENE-040718-25
Ensembl - ENSDARG00000028082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPKAPK5ENSGALG00000004743Gallus gallus
 Q8IW41ENSG00000089022Homo sapiens
 Gm42878ENSMUSG00000105340Mus musculus
 O54992ENSMUSG00000029454Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mapkapk2a / mitogen-activated protein kinase-activated protein kinase 2a / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...ENSDARG0000000255233
mapkapk2b / mitogen-activated protein kinase-activated protein kinase 2b / P49138* / P49137* / MAPKAPK2* / MAP kinase-activated protein kinase 2 * / mitogen-activated protein kinase-activat...ENSDARG0000001853032
mapkapk3 / mitogen-activated protein kinase-activated protein kinase 3 / Q16644*ENSDARG0000011161232
mknk2a / MAP kinase interacting serine/threonine kinase 2a / MKNK2* / Q8CDB0* / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2* / MAP kinase-interacting serine/threonine-protein...ENSDARG0000001137324
mknk2b / MAP kinase interacting serine/threonine kinase 2b / MKNK2* / Q8CDB0* / Q9HBH9* / MAP kinase interacting serine/threonine kinase 2* / MAP kinase-interacting serine/threonine-protein...ENSDARG0000001516424
mknk1 / MAP kinase interacting serine/threonine kinase 1 / Q9BUB5*ENSDARG0000001841123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR027442  MAP kinase activated protein kinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0046777 protein autophosphorylation IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
MAPK6/MAPK4 signaling
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000110581 mapk4 / mitogen-activated protein kinase 4 / P31152* / Q6P5G0*  / reaction / complex
 ENSDARG00000045836 mapk11 / mitogen-activated protein kinase 11 / Q15759* / Q9WUI1*  / complex
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / complex
 ENSDARG00000032103 mapk6 / mitogen-activated protein kinase 6 / Q16659* / Q61532*  / reaction / complex
 ENSDARG00000059125 prkacbb / protein kinase, cAMP-dependent, catalytic, beta b / P22694* / PRKACB* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSDARG00000041065 hspb1 / heat shock protein, alpha-crystallin-related, 1 / P14602* / P04792* / Heat shock protein beta-1 * / heat shock protein family B (small) member 1*  / reaction
 ENSDARG00000062390 cdc42ep5 / CDC42 effector protein (Rho GTPase binding) 5 / Q6NZY7* / Q9Z0X0* / 1700027J19Rik* / CDC42 effector protein 5*  / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / reaction
 ENSDARG00000061549 A3RK75 / foxo1b / forkhead box O1 b / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *  / reaction
 ENSDARG00000053959 cdc42ep2 / CDC42 effector protein (Rho GTPase binding) 2 / O14613* / Q8JZX9* / CDC42 effector protein 2*  / reaction
 ENSDARG00000052783 cdc42ep3 / CDC42 effector protein (Rho GTPase binding) 3 / Q9UKI2* / CDC42 effector protein 3*  / reaction
 ENSDARG00000023058 foxo3a / forkhead box O3A / FOXO3* / O43524* / Q9WVH4* / forkhead box O3* / Forkhead box protein O3 *  / reaction
 ENSDARG00000099555 A3RK74 / foxo1a / forkhead box O1 a / FOXO1* / Q9R1E0* / Q12778* / forkhead box O1* / Forkhead box protein O1 *  / reaction
 ENSDARG00000099184 map2k6 / Q9DGE0 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr