ENSDARG00000059125


Danio rerio

Features
Gene ID: ENSDARG00000059125
  
Biological name :prkacbb
  
Synonyms : prkacbb / protein kinase, cAMP-dependent, catalytic, beta b
  
Possible biological names infered from orthology : P22694 / P68181 / PRKACB / protein kinase cAMP-activated catalytic subunit beta / protein kinase, cAMP dependent, catalytic, beta
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 1594344
Gene end: 1622641
  
Corresponding Affymetrix probe sets: Dr.13715.1.S1_at (Zebrafish Array)   Dr.16829.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000076580
NCBI entrez gene - 563147     See in Manteia.
RefSeq - XM_005171094
RefSeq Peptide - NP_001030148
swissprot - Q3ZB92
ZFIN ID - ZDB-GENE-050904-4
Ensembl - ENSDARG00000059125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKACBENSGALG00000028530Gallus gallus
 P22694ENSG00000142875Homo sapiens
 P68181ENSMUSG00000005034Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkacaa / protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate aENSDARG0000010034991
prkacab / protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate bENSDARG0000001680989
prkacba / protein kinase, cAMP-dependent, catalytic, beta aENSDARG0000000178284
prkx / protein kinase, X-linked / P51817* / Q922R0* / cAMP-dependent protein kinase catalytic subunit PRKX *ENSDARG0000006071649
prkg1b / protein kinase, cGMP-dependent, type Ib / PRKG1* / P0C605* / Q13976* / protein kinase, cGMP-dependent, type I*ENSDARG0000003170242
prkg1a / protein kinase, cGMP-dependent, type IaENSDARG0000002065641
prkg2 / protein kinase, cGMP-dependent, type II / Q13237*ENSDARG0000005474140
si:dkey-121j17.5ENSDARG0000001423239


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
CREB phosphorylation through the activation of Adenylate Cyclase
Hedgehog off state
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
HDL assembly
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000033184 prkar2aa / protein kinase, cAMP-dependent, regulatory, type II, alpha A / P13861* / PRKAR2A* / protein kinase, cAMP dependent regulatory, type II alpha* / protein kinase cAMP-dependent type...  / complex
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / reaction
 ENSDARG00000074635 abca1a / ATP-binding cassette, sub-family A (ABC1), member 1A / ABCA1* / P41233* / O95477* / ATP binding cassette subfamily A member 1* / ATP-binding cassette, sub-family A (ABC1), member 1*  / reaction
 ENSDARG00000059125 prkacbb / protein kinase, cAMP-dependent, catalytic, beta b / P22694* / PRKACB* / protein kinase cAMP-activated catalytic subunit beta*  / complex
 ENSDARG00000028082 mapkapk5 / mitogen-activated protein kinase-activated protein kinase 5 / Q8IW41*  / reaction
 ENSDARG00000061551 rap1gap2a / RAP1 GTPase activating protein 2a / Q5SVL6* / Q684P5* / RAP1GAP2* / RAP1 GTPase activating protein 2*  / reaction
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / reaction
 ENSDARG00000059549 akap10 / A kinase (PRKA) anchor protein 10 / O43572* / O88845* / A-kinase anchoring protein 10* / A-kinase anchor protein 10, mitochondrial *  / reaction / complex
 ENSDARG00000006062 akap1b / A kinase (PRKA) anchor protein 1b / AKAP1* / O08715* / Q92667* / A-kinase anchoring protein 1* / A-kinase anchor protein 1, mitochondrial *  / reaction / complex
 ENSDARG00000009477 prkar2ab / protein kinase, cAMP-dependent, regulatory, type II, alpha, B / P13861* / PRKAR2A* / protein kinase cAMP-dependent type II regulatory subunit alpha*  / complex
 ENSDARG00000103800 prkar1b / protein kinase, cAMP-dependent, regulatory, type I, beta / P12849* / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*  / complex






 

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