ENSDARG00000054741


Danio rerio

Features
Gene ID: ENSDARG00000054741
  
Biological name :prkg2
  
Synonyms : prkg2 / protein kinase, cGMP-dependent, type II
  
Possible biological names infered from orthology : Q13237
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 39679767
Gene end: 39702345
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000071397
Ensembl peptide - ENSDARP00000143832
NCBI entrez gene - 100125912     See in Manteia.
RefSeq - NM_001105279
RefSeq Peptide - NP_001098749
swissprot - A2AVJ3
swissprot - A0A286Y9K1
ZFIN ID - ZDB-GENE-060531-80
Ensembl - ENSDARG00000054741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRKG2ENSGALG00000010909Gallus gallus
 PRKG2ENSG00000138669Homo sapiens
 Prkg2ENSMUSG00000029334Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prkg1b / protein kinase, cGMP-dependent, type Ib / PRKG1* / P0C605* / Q13976* / protein kinase, cGMP-dependent, type I*ENSDARG0000003170245
prkg1a / protein kinase, cGMP-dependent, type IaENSDARG0000002065643
si:dkey-121j17.5ENSDARG0000001423233
prkacaa / protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate aENSDARG0000010034919
prkx / protein kinase, X-linked / P51817* / Q922R0* / cAMP-dependent protein kinase catalytic subunit PRKX *ENSDARG0000006071619
prkacba / protein kinase, cAMP-dependent, catalytic, beta aENSDARG0000000178219
prkacbb / protein kinase, cAMP-dependent, catalytic, beta b / P22694* / PRKACB* / protein kinase cAMP-activated catalytic subunit beta*ENSDARG0000005912518
prkacab / protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate bENSDARG0000001680918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002374  cGMP-dependent kinase
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014710  RmlC-like jelly roll fold
 IPR017441  Protein kinase, ATP binding site
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR035014  cGMP-dependent protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004692 cGMP-dependent protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030553 cGMP binding IEA


Pathways (from Reactome)
Pathway description
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000074602 mrvi1 / murine retrovirus integration site 1 homolog / Q9WUX5* / Q9Y6F6* / Protein MRVI1 *  / reaction
 ENSDARG00000058553 sprb / sepiapterin reductase b / SPR* / P35270* / sepiapterin reductase*  / reaction
 ENSDARG00000014655 itpr1a / inositol 1,4,5-trisphosphate receptor, type 1a / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*  / reaction
 ENSDARG00000004406 spra / sepiapterin reductase a / SPR* / P35270* / sepiapterin reductase*  / reaction






 

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