ENSDARG00000014655


Danio rerio

Features
Gene ID: ENSDARG00000014655
  
Biological name :itpr1a
  
Synonyms : inositol 1,4,5-trisphosphate receptor, type 1a / itpr1a
  
Possible biological names infered from orthology : inositol 1,4,5-trisphosphate receptor type 1 / ITPR1 / P11881 / Q14643
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 39923052
Gene end: 39991554
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000152700
Ensembl peptide - ENSDARP00000155491
Ensembl peptide - ENSDARP00000065091
Ensembl peptide - ENSDARP00000123931
Ensembl peptide - ENSDARP00000151640
Ensembl peptide - ENSDARP00000152154
Ensembl peptide - ENSDARP00000152307
NCBI entrez gene - 567611     See in Manteia.
RefSeq - XM_017356665
RefSeq - XM_009302588
RefSeq - XM_021474617
RefSeq - XM_021474618
swissprot - F8W4B1
swissprot - E7F4G8
ZFIN ID - ZDB-GENE-070604-3
Ensembl - ENSDARG00000014655
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ITPR1ENSGALG00000008294Gallus gallus
 ITPR1ENSG00000150995Homo sapiens
 Itpr1ENSMUSG00000030102Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
itpr1b / inositol 1,4,5-trisphosphate receptor, type 1b / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*ENSDARG0000007414983
itpr3 / inositol 1,4,5-trisphosphate receptor, type 3 / P70227* / Q14573*ENSDARG0000006174158
itpr2 / inositol 1,4,5-trisphosphate receptor, type 2 / Q14571* / Q9Z329*ENSDARG0000001190946
ryr3 / ryanodine receptor 3 / A2AGL3* / Q15413*ENSDARG0000007133123
ryr1a / ryanodine receptor 1a (skeletal) / RYR1* / P21817* / E9PZQ0* / ryanodine receptor 1*ENSDARG0000001142222
ryr1b / ryanodine receptor 1b (skeletal) / RYR1* / P21817* / ryanodine receptor 1*ENSDARG0000002379722
RYR2 / ryanodine receptor 2 / Q92736*ENSDARG0000009885621
ryr2b / ryanodine receptor 2b (cardiac)ENSDARG0000000370621
FO834850.1 / ITPR2* / Q14571* / inositol 1,4,5-trisphosphate receptor type 2*ENSDARG0000011126111
CABZ01083778.1ENSDARG000001154241


Protein motifs (from Interpro)
Interpro ID Name
 IPR000493  Inositol 1,4,5-trisphosphate receptor
 IPR000699  RIH domain
 IPR005821  Ion transport domain
 IPR011989  Armadillo-like helical
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016093  MIR motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
cGMP effects
Ion homeostasis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031702 prkg1b / protein kinase, cGMP-dependent, type Ib / PRKG1* / P0C605* / Q13976* / protein kinase, cGMP-dependent, type I*  / reaction
 ENSDARG00000061560 stim1b / stromal interaction molecule 1b / STIM1* / Q13586* / P70302* / stromal interaction molecule 1*  / reaction
 ENSDARG00000074602 mrvi1 / murine retrovirus integration site 1 homolog / Q9WUX5* / Q9Y6F6* / Protein MRVI1 *  / complex
 ENSDARG00000060723 stim1a / stromal interaction molecule 1a / STIM1* / Q13586* / P70302* / stromal interaction molecule 1*  / reaction
 ENSDARG00000014655 itpr1a / inositol 1,4,5-trisphosphate receptor, type 1a / ITPR1* / P11881* / Q14643* / inositol 1,4,5-trisphosphate receptor type 1*  / complex
 ENSDARG00000054741 prkg2 / protein kinase, cGMP-dependent, type II / Q13237*  / reaction
 ENSDARG00000056331 ahcyl1 / adenosylhomocysteinase-like 1 / O43865* / Q80SW1* / Mus musculus S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), transcript variant 5, mRNA.*  / complex / reaction






 

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