ENSGALG00000008294


Gallus gallus

Features
Gene ID: ENSGALG00000008294
  
Biological name :ITPR1
  
Synonyms : inositol 1,4,5-trisphosphate receptor type 1 / ITPR1
  
Possible biological names infered from orthology : P11881 / Q14643
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 18440425
Gene end: 18591147
  
Corresponding Affymetrix probe sets: Gga.223.1.S1_at (Chicken Array)   Gga.4481.1.S1_at (Chicken Array)   GgaAffx.22521.1.S1_at (Chicken Array)   GgaAffx.5239.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052903
Ensembl peptide - ENSGALP00000054599
Ensembl peptide - ENSGALP00000013491
NCBI entrez gene - 395412     See in Manteia.
RefSeq - XM_015292953
RefSeq - XM_015292949
RefSeq - XM_015292950
RefSeq - XM_015292951
RefSeq - XM_015292952
RefSeq - NM_001174059
RefSeq - XM_015292941
RefSeq - XM_015292942
RefSeq - XM_015292943
RefSeq - XM_015292944
RefSeq - XM_015292945
RefSeq - XM_015292946
RefSeq - XM_015292947
RefSeq - XM_015292948
RefSeq Peptide - NP_001167530
swissprot - A0A1D5PP03
swissprot - F1NZV1
swissprot - A0A1D5PJB1
Ensembl - ENSGALG00000008294
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itpr1aENSDARG00000014655Danio rerio
 itpr1bENSDARG00000074149Danio rerio
 ITPR1ENSG00000150995Homo sapiens
 Itpr1ENSMUSG00000030102Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITPR3 / inositol 1,4,5-trisphosphate receptor type 3 / P70227* / Q14573*ENSGALG0000000314962
ENSGALG0000001407159
RYR2 / ryanodine receptor 2 / E9Q401* / Q92736* / ryanodine receptor 2, cardiac*ENSGALG0000001081224
RYR3 / ryanodine receptor 3 / A2AGL3* / Q15413*ENSGALG0000000970523
ENSGALG000000433017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000493  Inositol 1,4,5-trisphosphate receptor
 IPR000699  RIH domain
 IPR005821  Ion transport domain
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016024  Armadillo-type fold
 IPR016093  MIR motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0042045 epithelial fluid transport IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0050849 negative regulation of calcium-mediated signaling IEA
 biological_processGO:0050882 voluntary musculoskeletal movement IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005955 calcineurin complex IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0031088 platelet dense granule membrane IEA
 cellular_componentGO:0031094 platelet dense tubular network IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0015278 calcium-release channel activity IEA
 molecular_functionGO:0019855 calcium channel inhibitor activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
cGMP effects
Ion homeostasis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003805 PRKG1 / protein kinase, cGMP-dependent, type I / P0C605* / Q13976*  / reaction
 ENSGALG00000008294 ITPR1 / inositol 1,4,5-trisphosphate receptor type 1 / P11881* / Q14643*  / complex
 ENSGALG00000010909 PRKG2 / protein kinase, cGMP-dependent, type II / Q13237*  / reaction






 

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