ENSGALG00000010812


Gallus gallus

Features
Gene ID: ENSGALG00000010812
  
Biological name :RYR2
  
Synonyms : ryanodine receptor 2 / RYR2
  
Possible biological names infered from orthology : E9Q401 / Q92736 / ryanodine receptor 2, cardiac
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 37306402
Gene end: 37666241
  
Corresponding Affymetrix probe sets: GgaAffx.6834.2.S1_s_at (Chicken Array)   GgaAffx.6834.4.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049908
Ensembl peptide - ENSGALP00000017561
NCBI entrez gene - 421508     See in Manteia.
RefSeq - XM_015284422
RefSeq - XM_015284420
RefSeq - XM_015284421
swissprot - F1NLZ9
swissprot - A0A1D5PAZ1
Ensembl - ENSGALG00000010812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RYR2ENSDARG00000098856Danio rerio
 RYR2ENSG00000198626Homo sapiens
 Ryr2ENSMUSG00000021313Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RYR3 / ryanodine receptor 3 / A2AGL3* / Q15413*ENSGALG0000000970568
ITPR3 / inositol 1,4,5-trisphosphate receptor type 3 / P70227* / Q14573*ENSGALG0000000314913
ITPR1 / inositol 1,4,5-trisphosphate receptor type 1 / P11881* / Q14643*ENSGALG0000000829413
ENSGALG0000001407111
ENSGALG000000433011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000699  RIH domain
 IPR001870  B30.2/SPRY domain
 IPR002048  EF-hand domain
 IPR003032  Ryanodine receptor Ryr
 IPR003877  SPRY domain
 IPR005821  Ion transport domain
 IPR009460  Ryanodine Receptor TM 4-6
 IPR011992  EF-hand domain pair
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013333  Ryanodine receptor
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016093  MIR motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0003143 embryonic heart tube morphogenesis IEA
 biological_processGO:0003220 left ventricular cardiac muscle tissue morphogenesis IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0005513 detection of calcium ion IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IEA
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IEA
 biological_processGO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0031000 response to caffeine IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source IEA
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051284 positive regulation of sequestering of calcium ion IEA
 biological_processGO:0051775 response to redox state IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060401 cytosolic calcium ion transport IEA
 biological_processGO:0060402 calcium ion transport into cytosol IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071313 cellular response to caffeine IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 biological_processGO:0072599 establishment of protein localization to endoplasmic reticulum IEA
 biological_processGO:0086005 ventricular cardiac muscle cell action potential IEA
 biological_processGO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling IEA
 biological_processGO:0097050 type B pancreatic cell apoptotic process IEA
 biological_processGO:0098735 positive regulation of the force of heart contraction IEA
 biological_processGO:0098904 regulation of AV node cell action potential IEA
 biological_processGO:0098907 regulation of SA node cell action potential IEA
 biological_processGO:0098910 regulation of atrial cardiac muscle cell action potential IEA
 biological_processGO:0098911 regulation of ventricular cardiac muscle cell action potential IEA
 biological_processGO:1901896 positive regulation of calcium-transporting ATPase activity IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0034704 calcium channel complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005219 ryanodine-sensitive calcium-release channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0015278 calcium-release channel activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0043924 suramin binding IEA
 molecular_functionGO:0048763 calcium-induced calcium release activity IEA
 molecular_functionGO:0097159 organic cyclic compound binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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