ENSMUSG00000029334


Mus musculus

Features
Gene ID: ENSMUSG00000029334
  
Biological name :Prkg2
  
Synonyms : Prkg2 / protein kinase, cGMP-dependent, type II
  
Possible biological names infered from orthology : Q13237
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E3
Gene start: 98929773
Gene end: 99037351
  
Corresponding Affymetrix probe sets: 10531588 (MoGene1.0st)   1421354_at (Mouse Genome 430 2.0 Array)   1435162_at (Mouse Genome 430 2.0 Array)   1435460_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124963
Ensembl peptide - ENSMUSP00000143708
Ensembl peptide - ENSMUSP00000142743
Ensembl peptide - ENSMUSP00000031277
NCBI entrez gene - 19092     See in Manteia.
MGI - MGI:108173
RefSeq - NM_008926
RefSeq Peptide - NP_032952
swissprot - A0A0G2JEE8
swissprot - E9QPH0
swissprot - Q3TMJ2
swissprot - Q8CAH8
Ensembl - ENSMUSG00000029334
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkg2ENSDARG00000054741Danio rerio
 PRKG2ENSGALG00000010909Gallus gallus
 PRKG2ENSG00000138669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkg1 / P0C605 / protein kinase, cGMP-dependent, type I / Q13976*ENSMUSG0000005292047
P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*ENSMUSG0000000503421
P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*ENSMUSG0000000546920
Prkx / Q922R0 / cAMP-dependent protein kinase catalytic subunit PRKX / P51817* / protein kinase, X-linked*ENSMUSG0000003572519


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002374  cGMP-dependent kinase
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014710  RmlC-like jelly roll fold
 IPR017441  Protein kinase, ATP binding site
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR035014  cGMP-dependent protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:2001226 negative regulation of chloride transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004692 cGMP-dependent protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0004610 small vertebrae "reduced size of the bony segments of the spinal column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Fkbp8tm1Tili/Fkbp8tm1Tili,Shhtm1Chg/Shhtm1Chg
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030102 Itpr1 / P11881 / Inositol 1,4,5-trisphosphate receptor type 1 / Q14643*  / reaction
 ENSMUSG00000005611 Mrvi1 / Q9WUX5 / Protein MRVI1 / Q9Y6F6* / murine retrovirus integration site 1 homolog*  / reaction
 ENSMUSG00000033735 Spr / sepiapterin reductase / P35270*  / reaction
 ENSMUSG00000032067 Pts / Q9R1Z7 / 6-pyruvoyl-tetrahydropterin synthase / Q03393* / 6-pyruvoyltetrahydropterin synthase*  / reaction






 

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