ENSMUSG00000005611


Mus musculus

Features
Gene ID: ENSMUSG00000005611
  
Biological name :Mrvi1
  
Synonyms : Mrvi1 / Protein MRVI1 / Q9WUX5
  
Possible biological names infered from orthology : murine retrovirus integration site 1 homolog / Q9Y6F6
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 110868266
Gene end: 110982461
  
Corresponding Affymetrix probe sets: 10566943 (MoGene1.0st)   1422245_a_at (Mouse Genome 430 2.0 Array)   1459665_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005751
Ensembl peptide - ENSMUSP00000114578
Ensembl peptide - ENSMUSP00000120045
Ensembl peptide - ENSMUSP00000120765
NCBI entrez gene - 17540     See in Manteia.
MGI - MGI:1338023
RefSeq - XM_011241686
RefSeq - NM_010826
RefSeq - NM_194464
RefSeq - XM_006507415
RefSeq - XM_006507416
RefSeq - XM_006507418
RefSeq Peptide - NP_034956
RefSeq Peptide - NP_919446
swissprot - Q3UR44
swissprot - G5E8V5
swissprot - Q9WUX5
swissprot - D3YUG8
Ensembl - ENSMUSG00000005611
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mrvi1ENSDARG00000074602Danio rerio
 MRVI1ENSGALG00000005632Gallus gallus
 MRVI1ENSG00000072952Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrmp / lymphoid-restricted membrane protein isoform 2 / Q12912* / lymphoid restricted membrane protein*ENSMUSG0000003026312


Protein motifs (from Interpro)
Interpro ID Name
 IPR008677  MRVI1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019934 cGMP-mediated signaling IMP
 biological_processGO:0045986 negative regulation of smooth muscle contraction IMP
 biological_processGO:0060087 relaxation of vascular smooth muscle IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

Allelic Composition: Mrvi1tm1Jens/Mrvi1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0003157 impaired muscle relaxation "reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510]
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens,Taglntm2(PRKG1*)Hfm/Taglntm2(PRKG1*)Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003285 gastric hypertrophy "increase in the bulk size of the stomach due to cell enlargement or accumulation of fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0003307 pyloric stenosis "a narrowing of the gastric outlet of the stomach, often due to muscular hypertrophy or scarring from local inflammation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mrvi1tm2.1Jens/Mrvi1tm2.1Jens
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030102 Itpr1 / P11881 / Inositol 1,4,5-trisphosphate receptor type 1 / Q14643*  / complex
 ENSMUSG00000029334 Prkg2 / protein kinase, cGMP-dependent, type II / Q13237*  / reaction
 ENSMUSG00000052920 Prkg1 / P0C605 / protein kinase, cGMP-dependent, type I / Q13976*  / reaction






 

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