ENSMUSG00000033735


Mus musculus

Features
Gene ID: ENSMUSG00000033735
  
Biological name :Spr
  
Synonyms : sepiapterin reductase / Spr
  
Possible biological names infered from orthology : P35270
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 85130176
Gene end: 85137766
  
Corresponding Affymetrix probe sets: 10545807 (MoGene1.0st)   1432372_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048111
Ensembl peptide - ENSMUSP00000133859
Ensembl peptide - ENSMUSP00000134379
Ensembl peptide - ENSMUSP00000145412
NCBI entrez gene - 20751     See in Manteia.
MGI - MGI:103078
RefSeq - NM_011467
RefSeq Peptide - NP_035597
swissprot - Q91XH5
swissprot - G3UXX3
swissprot - G3UZ79
Ensembl - ENSMUSG00000033735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spraENSDARG00000004406Danio rerio
 sprbENSDARG00000058553Danio rerio
 SPRENSGALG00000000067Gallus gallus
 SPRENSG00000116096Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR006393  Sepiapterin reductase
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006729 tetrahydrobiopterin biosynthetic process IEA
 biological_processGO:0006809 nitric oxide biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004757 sepiapterin reductase activity IEA


Pathways (from Reactome)
Pathway description
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0002204 abnormal neurotransmitter physiology "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005320 abnormal biopterin level "anomalous concentration of this pterin found in yeast, the fruit fly and in normal human urine, the reduced form of which acts as a coenzyme for many enzymatic reactions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84533]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005321 abnormal neopterin level "anomalous concentration of this pteridine derivative, which is present in body fluids and is a precursor in the biosynthesis of biopterin; elevated levels result from immune activation, malignant disease, allograft rejection, and viral infection" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84533]
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Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Rpgrtm1Tili/Rpgrtm1Tili,Rpgrip1tm1Tili/Rpgrip1tm1Tili
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005664 decreased circulating noradrenaline level "less than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029334 Prkg2 / protein kinase, cGMP-dependent, type II / Q13237*  / reaction
 ENSMUSG00000033735 Spr / sepiapterin reductase / P35270*  / complex






 

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