ENSG00000140836


Homo sapiens

Features
Gene ID: ENSG00000140836
  
Biological name :ZFHX3
  
Synonyms : Q15911 / ZFHX3 / zinc finger homeobox 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.3
Gene start: 72782885
Gene end: 73891871
  
Corresponding Affymetrix probe sets: 208033_s_at (Human Genome U133 Plus 2.0 Array)   226137_at (Human Genome U133 Plus 2.0 Array)   233751_at (Human Genome U133 Plus 2.0 Array)   233752_s_at (Human Genome U133 Plus 2.0 Array)   242738_s_at (Human Genome U133 Plus 2.0 Array)   243323_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000268489
Ensembl peptide - ENSP00000438926
Ensembl peptide - ENSP00000493252
NCBI entrez gene - 463     See in Manteia.
OMIM - 104155
RefSeq - XM_017023251
RefSeq - NM_001164766
RefSeq - NM_006885
RefSeq - XM_005255957
RefSeq Peptide - NP_001158238
RefSeq Peptide - NP_008816
swissprot - Q15911
Ensembl - ENSG00000140836
  
Related genetic diseases (OMIM): 176807 - {Prostate cancer, susceptibility to, somatic}, 176807

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfhx3ENSDARG00000103057Danio rerio
 ZFHX3ENSGALG00000000713Gallus gallus
 Zfhx3ENSMUSG00000038872Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ZFHX4 / Q86UP3 / zinc finger homeobox 4ENSG0000009165654
ZFHX2 / Q9C0A1 / zinc finger homeobox 2ENSG0000013636726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003604  Matrin/U1-C-like, C2H2-type zinc finger
 IPR009057  Homeobox-like domain superfamily
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR017970  Homeobox, conserved site
 IPR026939  At2g23090-like
 IPR036236  Zinc finger C2H2 superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0071559 response to transforming growth factor beta IDA
 biological_processGO:1904059 regulation of locomotor rhythm ISS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
RUNX3 regulates CDKN1A transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000020633 RUNX3 / Q13761 / runt related transcription factor 3  / complex






 

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