ENSMUSG00000038872


Mus musculus

Features
Gene ID: ENSMUSG00000038872
  
Biological name :Zfhx3
  
Synonyms : Zfhx3 / zinc finger homeobox 3
  
Possible biological names infered from orthology : Q15911
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 107942644
Gene end: 108961630
  
Corresponding Affymetrix probe sets: 10575213 (MoGene1.0st)   1420649_at (Mouse Genome 430 2.0 Array)   1420650_at (Mouse Genome 430 2.0 Array)   1429725_at (Mouse Genome 430 2.0 Array)   1449947_s_at (Mouse Genome 430 2.0 Array)   1453267_at (Mouse Genome 430 2.0 Array)   1460006_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140025
Ensembl peptide - ENSMUSP00000152353
Ensembl peptide - ENSMUSP00000044612
NCBI entrez gene - 11906     See in Manteia.
MGI - MGI:99948
RefSeq - XM_006530585
RefSeq - XM_011248284
RefSeq - NM_007496
RefSeq - XM_006530586
RefSeq Peptide - NP_031522
swissprot - E9QMD3
swissprot - A0A087WQ36
Ensembl - ENSMUSG00000038872
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfhx3ENSDARG00000103057Danio rerio
 ZFHX3ENSGALG00000000713Gallus gallus
 ZFHX3ENSG00000140836Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfhx4 / zinc finger homeodomain 4 / Q86UP3* / zinc finger homeobox 4*ENSMUSG0000002525553
Zfhx2 / zinc finger homeobox 2 / Q9C0A1*ENSMUSG0000004072125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003604  Matrin/U1-C-like, C2H2-type zinc finger
 IPR009057  Homeobox-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017970  Homeobox, conserved site
 IPR026939  At2g23090-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0071559 response to transforming growth factor beta IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RUNX3 regulates CDKN1A transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp1tm1Ajmr/Lrp1tm1Ajmr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0020474 advanced circadian behavior phase "increase in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
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Allelic Composition: Hba-a1tm1Ywk/Hba-a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / complex






 

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