ENSG00000091656


Homo sapiens

Features
Gene ID: ENSG00000091656
  
Biological name :ZFHX4
  
Synonyms : Q86UP3 / ZFHX4 / zinc finger homeobox 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q21.13
Gene start: 76681219
Gene end: 76867285
  
Corresponding Affymetrix probe sets: 1559270_at (Human Genome U133 Plus 2.0 Array)   219779_at (Human Genome U133 Plus 2.0 Array)   241700_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427775
Ensembl peptide - ENSP00000428525
Ensembl peptide - ENSP00000431101
Ensembl peptide - ENSP00000430848
Ensembl peptide - ENSP00000430497
Ensembl peptide - ENSP00000430375
Ensembl peptide - ENSP00000429495
Ensembl peptide - ENSP00000427739
NCBI entrez gene - 79776     See in Manteia.
OMIM - 606940
RefSeq - XM_011517592
RefSeq - XM_017013845
RefSeq - XM_011517597
RefSeq - XM_011517596
RefSeq - XM_011517595
RefSeq - XM_011517594
RefSeq - XM_011517593
RefSeq - NM_024721
RefSeq Peptide - NP_078997
swissprot - Q86UP3
swissprot - E7EVZ1
swissprot - H0YC81
swissprot - H0YBV0
swissprot - E5RG79
swissprot - E5RGK3
swissprot - E5RHS1
swissprot - E5RI93
Ensembl - ENSG00000091656
  
Related genetic diseases (OMIM): 178300 - ?Ptosis, congenital, 178300

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zfhx4ENSDARG00000075542Danio rerio
 ZFHX4ENSGALG00000037164Gallus gallus
 Zfhx4ENSMUSG00000025255Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ZFHX3 / Q15911 / zinc finger homeobox 3ENSG0000014083656
ZFHX2 / Q9C0A1 / zinc finger homeobox 2ENSG0000013636726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003604  Matrin/U1-C-like, C2H2-type zinc finger
 IPR009057  Homeobox-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR017970  Homeobox, conserved site
 IPR026939  At2g23090-like
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0007970 Congenital ptosis 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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