Manteia - Molecule gene

ENSMUSG00000000708

Mus musculus

Features

Gene ID:	ENSMUSG00000000708

Biological name :	Kat2b

Synonyms :	Histone acetyltransferase KAT2B / Kat2b / Q9JHD1

Possible biological names infered from orthology :	lysine acetyltransferase 2B / Q92831

Species:	Mus musculus

Chr. number:	17
Strand:	1
Band:	C
Gene start:	53566861
Gene end:	53672720

Corresponding Affymetrix probe sets:	10445909 (MoGene1.0st) 1434037_s_at (Mouse Genome 430 2.0 Array) 1450821_at (Mouse Genome 430 2.0 Array) 1457809_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000127807 Ensembl peptide - ENSMUSP00000000724 Ensembl peptide - ENSMUSP00000126232 Ensembl peptide - ENSMUSP00000127659 NCBI entrez gene - 18519 See in Manteia. MGI - MGI:1343094 RefSeq - XM_006523820 RefSeq - NM_001190846 RefSeq - NM_020005 RefSeq Peptide - NP_001177775 RefSeq Peptide - NP_064389 swissprot - B2RR30 swissprot - E9Q1F7 swissprot - F6ZCH1 swissprot - F6SIC5 swissprot - Q9JHD1 Ensembl - ENSMUSG00000000708

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
KAT2B	ENSG00000114166	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kat2a / Q9JHD2 / K(lysine) acetyltransferase 2A / Q92830* / lysine acetyltransferase 2A*	ENSMUSG00000020918	71
Bptf / bromodomain PHD finger transcription factor / Q12830*	ENSMUSG00000040481	27
Cecr2 / E9Q2Z1 / Cat eye syndrome critical region / Q9BXF3* / CECR2, histone acetyl-lysine reader*	ENSMUSG00000071226	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR000182	GNAT domain
IPR001487	Bromodomain
IPR009464	PCAF, N-terminal
IPR016181	Acyl-CoA N-acyltransferase
IPR016376	Histone acetyltransferase GCN5/PCAF
IPR018359	Bromodomain, conserved site
IPR036427	Bromodomain-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006338	chromatin remodeling	ISS
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006473	protein acetylation	TAS
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007507	heart development	ISS
biological_process	GO:0008285	negative regulation of cell proliferation	IEA
biological_process	GO:0010835	regulation of protein ADP-ribosylation	ISO
biological_process	GO:0016573	histone acetylation	IEA
biological_process	GO:0018076	N-terminal peptidyl-lysine acetylation	ISO
biological_process	GO:0018393	internal peptidyl-lysine acetylation	IMP
biological_process	GO:0018394	peptidyl-lysine acetylation	ISO
biological_process	GO:0032869	cellular response to insulin stimulus	ISO
biological_process	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter	IGI
biological_process	GO:0043966	histone H3 acetylation	IEA
biological_process	GO:0043970	histone H3-K9 acetylation	IGI
biological_process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0046600	negative regulation of centriole replication	ISS
biological_process	GO:0048511	rhythmic process	IEA
biological_process	GO:0060173	limb development	ISS
cellular_component	GO:0000123	histone acetyltransferase complex	IDA
cellular_component	GO:0000776	kinetochore	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005813	centrosome	IEA
cellular_component	GO:0005815	microtubule organizing center	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0031672	A band	IDA
cellular_component	GO:0031674	I band	IDA
cellular_component	GO:0032991	protein-containing complex	IEA
cellular_component	GO:0042641	actomyosin	IDA
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0003682	chromatin binding	IDA
molecular_function	GO:0003712	transcription coregulator activity	IEA
molecular_function	GO:0003713	transcription coactivator activity	IEA
molecular_function	GO:0004402	histone acetyltransferase activity	IEA
molecular_function	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO
molecular_function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008080	N-acetyltransferase activity	IEA
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0016407	acetyltransferase activity	EXP
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016746	transferase activity, transferring acyl groups	IEA
molecular_function	GO:0019901	protein kinase binding	IPI
molecular_function	GO:0042826	histone deacetylase binding	IEA
molecular_function	GO:0044877	protein-containing complex binding	IEA
molecular_function	GO:0061733	peptide-lysine-N-acetyltransferase activity	IEA

Pathways (from Reactome)

Pathway description

YAP1- and WWTR1 (TAZ)-stimulated gene expression

NOTCH1 Intracellular Domain Regulates Transcription

Notch-HLH transcription pathway

B-WICH complex positively regulates rRNA expression

Metalloprotease DUBs

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

RUNX3 regulates NOTCH signaling

Estrogen-dependent gene expression

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001718	abnormal yolk sac	"malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]	Show Allelic Composition: Fas^lpr/Fas^lpr,Ifng^tm1Ts/Ifng⁺ Genetic Background: MRL.Cg-Ifng^tm1Ts Fas^lpr
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fas^lpr/Fas^lpr,Ifng^tm1Ts/Ifng⁺ Genetic Background: MRL.Cg-Ifng^tm1Ts Fas^lpr
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hcn2^tm1Ldw/Hcn2^tm2Ldw,Myl7^tm1(cre)Krc/Myl7⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Kat2b^tm1Roth/Kat2b^tm1Roth Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kat2a^tm1Nkt/Kat2a^tm1Nkt,Kat2b^tm1Nkt/Kat2b^tm1Nkt Genetic Background: involves: 129X1/SvJ * CD-1 Allelic Composition: Kat2a^tm1Roth/Kat2a^tm1Roth,Kat2b^tm1Roth/Kat2b^tm1Roth Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Kat2a^tm1Nkt/Kat2a^tm1Nkt,Kat2b^tm1Nkt/Kat2b^tm1Nkt Genetic Background: involves: 129X1/SvJ * CD-1
MP:0011096	complete embryonic lethality before somite formation	"death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]	Show Allelic Composition: Kat2a^tm1Roth/Kat2a^tm1Roth,Kat2b^tm1Roth/Kat2b^tm1Roth Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000099517	P68433 / Hist1h3g / Histone H3.1	/ reaction
ENSMUSG00000100210	P84228 / Hist1h3f / Histone H3.2	/ reaction
ENSMUSG00000060743	H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*	/ reaction
ENSMUSG00000060981	P62806 / Hist1h4h / Histone H4	/ reaction
ENSMUSG00000020918	Kat2a / Q9JHD2 / K(lysine) acetyltransferase 2A / Q92830* / lysine acetyltransferase 2A*	/ complex / reaction
ENSMUSG00000018263	Tbx5 / P70326 / T-box 5 / Q99593*	/ complex / reaction
ENSMUSG00000027803	Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*	/ complex / reaction
ENSMUSG00000055024	Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*	/ complex / reaction
ENSMUSG00000062627	Mysm1 / Q69Z66 / Histone H2A deubiquitinase MYSM1 / Q5VVJ2* / Myb like, SWIRM and MPN domains 1*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr