ENSMUSG00000020918


Mus musculus

Features
Gene ID: ENSMUSG00000020918
  
Biological name :Kat2a
  
Synonyms : Kat2a / K(lysine) acetyltransferase 2A / Q9JHD2
  
Possible biological names infered from orthology : lysine acetyltransferase 2A / Q92830
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100704746
Gene end: 100712465
  
Corresponding Affymetrix probe sets: 10391221 (MoGene1.0st)   1422971_at (Mouse Genome 430 2.0 Array)   1422972_s_at (Mouse Genome 430 2.0 Array)   1426783_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006973
Ensembl peptide - ENSMUSP00000099407
NCBI entrez gene - 14534     See in Manteia.
MGI - MGI:1343101
RefSeq - XM_017314273
RefSeq - NM_001038010
RefSeq - NM_020004
RefSeq - XM_017314270
RefSeq - XM_017314271
RefSeq - XM_017314272
RefSeq Peptide - NP_001033099
RefSeq Peptide - NP_064388
swissprot - Q6P3Z8
swissprot - Q9JHD2
Ensembl - ENSMUSG00000020918
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kat2aENSDARG00000104734Danio rerio
 KAT2AENSGALG00000003369Gallus gallus
 KAT2AENSG00000108773Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kat2b / Q9JHD1 / Histone acetyltransferase KAT2B / Q92831* / lysine acetyltransferase 2B*ENSMUSG0000000070870
Bptf / bromodomain PHD finger transcription factor / Q12830*ENSMUSG0000004048125
Cecr2 / E9Q2Z1 / Cat eye syndrome critical region / Q9BXF3* / CECR2, histone acetyl-lysine reader*ENSMUSG0000007122614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR001487  Bromodomain
 IPR009464  PCAF, N-terminal
 IPR016181  Acyl-CoA N-acyltransferase
 IPR016376  Histone acetyltransferase GCN5/PCAF
 IPR018359  Bromodomain, conserved site
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0016578 histone deubiquitination IEA
 biological_processGO:0018393 internal peptidyl-lysine acetylation IEA
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0022037 metencephalon development IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0031346 positive regulation of cell projection organization IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IGI
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043983 histone H4-K12 acetylation IDA
 biological_processGO:0044154 histone H3-K14 acetylation IDA
 biological_processGO:0045589 regulation of regulatory T cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046600 negative regulation of centriole replication IEA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0048312 intracellular distribution of mitochondria IEA
 biological_processGO:0050863 regulation of T cell activation IMP
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0060173 limb development ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071929 alpha-tubulin acetylation IEA
 biological_processGO:0106077 histone succinylation IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030914 STAGA complex IEA
 cellular_componentGO:0033276 transcription factor TFTC complex IEA
 cellular_componentGO:0045252 oxoglutarate dehydrogenase complex IEA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008080 N-acetyltransferase activity IDA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0010484 H3 histone acetyltransferase activity IEA
 molecular_functionGO:0016407 acetyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043997 histone acetyltransferase activity (H4-K12 specific) IDA
 molecular_functionGO:0061733 peptide-lysine-N-acetyltransferase activity IEA
 molecular_functionGO:0106078 histone succinyltransferase activity IEA


Pathways (from Reactome)
Pathway description
NOTCH1 Intracellular Domain Regulates Transcription
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Ub-specific processing proteases
RUNX3 regulates NOTCH signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0000847 abnormal metencephalon morphology "any malformation or absence of the anterior part of the rhombencephalon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000864 abnormal vermis "malformation in the narrow middle zone between the two hemispheres of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

Allelic Composition: Kat2atm3.1Roth/Kat2atm3.2Roth,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kat2atm3Roth/Kat2atm3Roth
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Kat2atm3Roth/Kat2atm3.1Roth
Genetic Background: involves: 129

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: 129-Kat2atm1Roth/Kat2atm3Roth

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kat2atm3Roth/Kat2atm3Roth
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0000932 absent notochord "missing axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Kat2atm3.1Roth/Kat2atm3.1Roth
Genetic Background: involves: 129

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Kat2atm3.1Roth/Kat2atm3.1Roth
Genetic Background: involves: 129

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7+,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

Allelic Composition: Kat2atm3.1Roth/Kat2atm3.2Roth,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm3.2Roth
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0001690 failure of somite differentiation "disorganized or absent somite tissue or somite pattern in development" [J:25248]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kat2atm3Roth/Kat2atm3Roth
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Kat2atm3Roth/Kat2atm3Roth
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Kat2atm3Roth/Kat2atm3.1Roth
Genetic Background: involves: 129

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: involves: C57BL/6N

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

Allelic Composition: Atxn7tm1Hzo/Atxn7+,Kat2atm3Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslpr/Faslpr,Ifngtm1Ts/Ifng+
Genetic Background: MRL.Cg-Ifngtm1Ts Faslpr

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm3.2Roth
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: WwoxGt(XG218)Byg/WwoxGt(XG218)Byg
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Kat2atm1Roth/Kat2atm3.2Roth
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Kat2btm1Roth/Kat2btm1Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Kat2atm1Roth/Kat2a+
Genetic Background: involves: 129/Sv * 129S7/SvEvBrd

 MP:0004680 small xiphoid process "reduced size of the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0008580 photoreceptor inner segment degeneration "retrogressive pathologic change in the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo,Kat2atm3.1Roth/Kat2a+
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kat2atm3Roth/Kat2atm3Roth
Genetic Background: involves: 129 * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Atxn7tm1Hzo/Atxn7tm1Hzo
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Kat2atm1Nkt/Kat2atm1Nkt,Kat2btm1Nkt/Kat2btm1Nkt
Genetic Background: involves: 129X1/SvJ * CD-1

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Kat2btm1Roth/Kat2btm1Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Kat2atm3.1Roth/Kat2atm3.1Roth
Genetic Background: involves: 129

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0012271 abnormal chordamesoderm morphology "any structural anomaly of the area of axial mesoderm that develops into the notochord" [MGI:anna]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012282 abnormal sternebra number "deviation from the average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
Show

Allelic Composition: Sptbn4qv-11J/Sptbn4qv-11J
Genetic Background: C57BL/6J-Sptbn4qv-11J/J

Allelic Composition: Kat2atm1Roth/Kat2atm3Roth
Genetic Background: involves: 129 * 129S7/SvEvBrd

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0013505 decreased embryonic tissue cell apoptosis "decrease in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Kat2atm1Roth/Kat2atm1Roth,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000708 Kat2b / Q9JHD1 / Histone acetyltransferase KAT2B / Q92831* / lysine acetyltransferase 2B*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr