ENSG00000108773


Homo sapiens

Features
Gene ID: ENSG00000108773
  
Biological name :KAT2A
  
Synonyms : KAT2A / lysine acetyltransferase 2A / Q92830
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.2
Gene start: 42113108
Gene end: 42121358
  
Corresponding Affymetrix probe sets: 202182_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000225916
Ensembl peptide - ENSP00000467324
Ensembl peptide - ENSP00000468390
NCBI entrez gene - 2648     See in Manteia.
OMIM - 602301
RefSeq - XM_017024448
RefSeq - NM_021078
RefSeq - XM_006721817
RefSeq - XM_006721818
RefSeq Peptide - NP_066564
swissprot - Q92830
swissprot - K7ERS6
swissprot - K7EPC4
Ensembl - ENSG00000108773
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kat2aENSDARG00000104734Danio rerio
 KAT2AENSGALG00000003369Gallus gallus
 Kat2aENSMUSG00000020918Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KAT2B / Q92831 / lysine acetyltransferase 2BENSG0000011416670
BPTF / Q12830 / bromodomain PHD finger transcription factorENSG0000017163426
CECR2 / Q9BXF3 / CECR2, histone acetyl-lysine readerENSG0000009995412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR001487  Bromodomain
 IPR009464  PCAF, N-terminal
 IPR016181  Acyl-CoA N-acyltransferase
 IPR016376  Histone acetyltransferase GCN5/PCAF
 IPR018359  Bromodomain, conserved site
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0006338 chromatin remodeling TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0016578 histone deubiquitination IDA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0018393 internal peptidyl-lysine acetylation IDA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0022037 metencephalon development IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0031346 positive regulation of cell projection organization IEA
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043983 histone H4-K12 acetylation IEA
 biological_processGO:0044154 histone H3-K14 acetylation IEA
 biological_processGO:0045589 regulation of regulatory T cell differentiation IEA
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046600 negative regulation of centriole replication IDA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048312 intracellular distribution of mitochondria IEA
 biological_processGO:0050863 regulation of T cell activation IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0060173 limb development ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071929 alpha-tubulin acetylation IEA
 biological_processGO:0106077 histone succinylation IDA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030914 STAGA complex IEA
 cellular_componentGO:0033276 transcription factor TFTC complex IDA
 cellular_componentGO:0045252 oxoglutarate dehydrogenase complex IDA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0010484 H3 histone acetyltransferase activity IDA
 molecular_functionGO:0016407 acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043997 histone acetyltransferase activity (H4-K12 specific) IEA
 molecular_functionGO:0061733 peptide-lysine-N-acetyltransferase activity IDA
 molecular_functionGO:0106078 histone succinyltransferase activity IDA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Ub-specific processing proteases
RNA Polymerase I Transcription Initiation
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114166 KAT2B / Q92831 / lysine acetyltransferase 2B  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex






 

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