ENSMUSG00000071226


Mus musculus

Features
Gene ID: ENSMUSG00000071226
  
Biological name :Cecr2
  
Synonyms : Cat eye syndrome critical region / Cecr2 / E9Q2Z1
  
Possible biological names infered from orthology : CECR2, histone acetyl-lysine reader / Q9BXF3
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F1
Gene start: 120666369
Gene end: 120771190
  
Corresponding Affymetrix probe sets: 10541260 (MoGene1.0st)   1431014_at (Mouse Genome 430 2.0 Array)   1457039_at (Mouse Genome 430 2.0 Array)   1459202_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098556
Ensembl peptide - ENSMUSP00000108306
Ensembl peptide - ENSMUSP00000116993
Ensembl peptide - ENSMUSP00000118542
NCBI entrez gene - 330409     See in Manteia.
MGI - MGI:1923799
RefSeq - XM_017321659
RefSeq - NM_001128151
RefSeq - XM_011241397
RefSeq - XM_011241398
RefSeq - XM_006506320
RefSeq - XM_011241396
RefSeq Peptide - NP_001121623
swissprot - E9Q2Z1
Ensembl - ENSMUSG00000071226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cecr2ENSDARG00000078310Danio rerio
 CECR2ENSGALG00000013034Gallus gallus
 CECR2ENSG00000099954Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bptf / bromodomain PHD finger transcription factor / Q12830*ENSMUSG0000004048118
Kat2b / Q9JHD1 / Histone acetyltransferase KAT2B / Q92831* / lysine acetyltransferase 2B*ENSMUSG000000007088
Kat2a / Q9JHD2 / K(lysine) acetyltransferase 2A / Q92830* / lysine acetyltransferase 2A*ENSMUSG000000209188


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR018359  Bromodomain, conserved site
 IPR029614  Cat eye syndrome critical region protein 2
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001842 neural fold formation IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling IEA
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:0097194 execution phase of apoptosis ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0031010 ISWI-type complex IPI
 cellular_componentGO:0090537 CERF complex IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Cecr2tm1.1Hemc/Cecr2tm1.1Hemc
Genetic Background: involves: FVB/N

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tg(Il1rn)1Dih/Tg(Il1rn)1Dih
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2+
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: 129P2/OlaHsd * BALB/c * FVB/N

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: C.129P2-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: 129P2(C)-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Cecr2tm1.1Hemc/Cecr2tm1.1Hemc
Genetic Background: involves: BALB/c

Allelic Composition: Cecr2tm1.1Hemc/Cecr2tm1.1Hemc
Genetic Background: involves: FVB/N

 MP:0001341 absent eyelids "missing skin folds covering the front of the eyeball when closed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tg(Il1rn)1Dih/Tg(Il1rn)1Dih
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2tm1.1Hemc/Cecr2tm1.1Hemc
Genetic Background: involves: BALB/c

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: 129P2/OlaHsd * BALB/c * FVB/N

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2+
Genetic Background: C.129P2-Cecr2Gt(pGT1)1Hemc

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0005382 craniofacial phenotype 
Show

Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tg(Il1rn)1Dih/Tg(Il1rn)1Dih
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
Show

Allelic Composition: Cecr2tm1.1Hemc/Cecr2tm1.1Hemc
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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