ENSMUSG00000040481


Mus musculus

Features
Gene ID: ENSMUSG00000040481
  
Biological name :Bptf
  
Synonyms : Bptf / bromodomain PHD finger transcription factor
  
Possible biological names infered from orthology : Q12830
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 107033081
Gene end: 107132127
  
Corresponding Affymetrix probe sets: 10392300 (MoGene1.0st)   10392318 (MoGene1.0st)   1427310_at (Mouse Genome 430 2.0 Array)   1427311_at (Mouse Genome 430 2.0 Array)   1439102_at (Mouse Genome 430 2.0 Array)   1456615_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052303
Ensembl peptide - ENSMUSP00000102374
Ensembl peptide - ENSMUSP00000102373
Ensembl peptide - ENSMUSP00000146600
Ensembl peptide - ENSMUSP00000122575
Ensembl peptide - ENSMUSP00000118875
NCBI entrez gene - 207165     See in Manteia.
MGI - MGI:2444008
RefSeq - XM_017314399
RefSeq - XM_006532685
RefSeq - XM_006532686
RefSeq - XM_006532687
RefSeq - XM_006532688
RefSeq - XM_006532689
RefSeq - XM_006532690
RefSeq - XM_006532691
RefSeq - NM_176850
RefSeq - XM_006532675
RefSeq - XM_006532676
RefSeq - XM_006532677
RefSeq - XM_006532678
RefSeq - XM_006532679
RefSeq - XM_006532680
RefSeq - XM_006532681
RefSeq - XM_006532682
RefSeq - XM_006532683
RefSeq - XM_006532684
RefSeq Peptide - NP_789820
swissprot - A2A655
swissprot - A2A654
swissprot - E9Q6A7
swissprot - A2A652
swissprot - A0A140LHY5
swissprot - A2A653
Ensembl - ENSMUSG00000040481
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bptfENSDARG00000077361Danio rerio
 BPTFENSGALG00000038222Gallus gallus
 BPTFENSG00000171634Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cecr2 / E9Q2Z1 / Cat eye syndrome critical region / Q9BXF3* / CECR2, histone acetyl-lysine reader*ENSMUSG000000712269
Kat2a / Q9JHD2 / K(lysine) acetyltransferase 2A / Q92830* / lysine acetyltransferase 2A*ENSMUSG000000209187
Kat2b / Q9JHD1 / Histone acetyltransferase KAT2B / Q92831* / lysine acetyltransferase 2B*ENSMUSG000000007087


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR001510  Zinc finger, PARP-type
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018359  Bromodomain, conserved site
 IPR018501  DDT domain
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR028941  WHIM2 domain
 IPR028942  WHIM1 domain
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016589 NURF complex ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048188 Set1C/COMPASS complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0035064 methylated histone binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bptftm1.2Cwu/Bptftm1.2Cwu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: BptfGt(XG023)Byg/Bptftm1.2Cwu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Bptftm1.2Cwu/Bptftm1.2Cwu
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: BptfGt(XG023)Byg/BptfGt(XG023)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: BptfGt(XG023)Byg/Bptftm1.2Cwu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: BptfGt(XG023)Byg/BptfGt(XG023)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: Bptftm1.2Cwu/Bptftm1.2Cwu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001705 abnormal proximal-distal axis patterning "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: BptfGt(XG023)Byg/Bptftm1.2Cwu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: BptfGt(XG023)Byg/BptfGt(XG023)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0002584 small ectoplacental cone 
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Allelic Composition: BptfGt(XG023)Byg/BptfGt(XG023)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: BptfGt(XG023)Byg/Bptftm1.2Cwu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Bptftm1.2Cwu/Bptftm1.2Cwu
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: BptfGt(XG023)Byg/BptfGt(XG023)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0011190 thick embryonic epiblast "increased thickness of the tissue derived from the inner cell mass that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper and to the extraembryonic mesoderm" [PMID:21123814]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0012159 absent anterior visceral endoderm "absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:anna]
Show

Allelic Composition: BptfGt(XG023)Byg/BptfGt(XG023)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0012161 absent distal visceral endoderm "absence of the precursors of the anterior visceral endoderm that arises at the distal tip of the embryo" [MGI:anna]
Show

Allelic Composition: BptfGt(XG023)Byg/BptfGt(XG023)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0012685 abnormal primitive streak elongation "any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length" [MGI:anna]
Show

Allelic Composition: Pdgfratm8Sor/Pdgfratm8Sor,Pdgfrbtm11Sor/Pdgfrbtm11Sor,Tg(Nr5a1-cre)2Klp/0
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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