ENSMUSG00000032531


Mus musculus

Features
Gene ID: ENSMUSG00000032531
  
Biological name :Amotl2
  
Synonyms : Amotl2 / Angiomotin-like protein 2 / Q8K371
  
Possible biological names infered from orthology : angiomotin like 2 / Q9Y2J4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 102716672
Gene end: 102733418
  
Corresponding Affymetrix probe sets: 10588226 (MoGene1.0st)   1452387_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114950
Ensembl peptide - ENSMUSP00000140688
Ensembl peptide - ENSMUSP00000121113
Ensembl peptide - ENSMUSP00000120378
Ensembl peptide - ENSMUSP00000119903
Ensembl peptide - ENSMUSP00000118176
Ensembl peptide - ENSMUSP00000118126
Ensembl peptide - ENSMUSP00000116554
Ensembl peptide - ENSMUSP00000115845
Ensembl peptide - ENSMUSP00000035121
NCBI entrez gene - 56332     See in Manteia.
MGI - MGI:1929286
RefSeq - XM_006511773
RefSeq - NM_019764
RefSeq - XM_006511771
RefSeq - XM_006511772
RefSeq Peptide - NP_062738
swissprot - B8JK81
swissprot - A0A087WRL8
swissprot - B8JK86
swissprot - B8JK87
swissprot - Q3TP05
swissprot - Q8K371
swissprot - B8JK85
swissprot - B8JK84
swissprot - B8JK82
swissprot - B8JK83
Ensembl - ENSMUSG00000032531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A1YB07ENSDARG00000061923Danio rerio
 amotl2bENSDARG00000061948Danio rerio
 ENSGALG00000006483Gallus gallus
 AMOTL2ENSG00000114019Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Amot / Q8VHG2 / Angiomotin / Q4VCS5*ENSMUSG0000004168843
Amotl1 / Q9D4H4 / Angiomotin-like protein 1 / Q8IY63* / angiomotin like 1*ENSMUSG0000001307642


Protein motifs (from Interpro)
Interpro ID Name
 IPR009114  Angiomotin
 IPR024646  Angiomotin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0035329 hippo signaling ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IDA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

Allelic Composition: Amotl2tm1.1Laho/Amotl2+,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

Allelic Composition: Amotl2tm1.1Laho/Amotl2+,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+,Pax7tm1(cre/ERT2)Gaka/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl

Allelic Composition: Amotl2tm1.1Laho/Amotl2+,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / reaction / complex
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / reaction / complex






 

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contact: otassy@igbmc.fr