ENSDARG00000061923


Danio rerio

Features
Gene ID: ENSDARG00000061923
  
Biological name :amotl2a
  
Synonyms : A1YB07 / amotl2a / angiomotin like 2a
  
Possible biological names infered from orthology : AMOTL2 / angiomotin like 2 / Angiomotin-like protein 2 / Q8K371 / Q9Y2J4
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 27991943
Gene end: 28001131
  
Corresponding Affymetrix probe sets: Dr.40.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000118007
Ensembl peptide - ENSDARP00000121125
Ensembl peptide - ENSDARP00000134595
Ensembl peptide - ENSDARP00000083347
Ensembl peptide - ENSDARP00000116113
swissprot - A1YB07
swissprot - E9QED7
swissprot - E9QGU3
swissprot - F1R5K3
ZFIN ID - ZDB-GENE-030131-9770
Ensembl - ENSDARG00000061923
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000006483Gallus gallus
 AMOTL2ENSG00000114019Homo sapiens
 Amotl2ENSMUSG00000032531Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
amot / angiomotin / Q4VCS5*ENSDARG0000007833542
amotl2b / angiomotin like 2b / AMOTL2* / Q8K371* / Q9Y2J4* / angiomotin like 2* / Angiomotin-like protein 2 *ENSDARG0000006194841
AMOTL1 / angiomotin like 1 / Q8IY63*ENSDARG0000001944238


Protein motifs (from Interpro)
Interpro ID Name
 IPR009114  Angiomotin
 IPR024646  Angiomotin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030866 cortical actin cytoskeleton organization IMP
 biological_processGO:0035912 dorsal aorta morphogenesis IMP
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0051649 establishment of localization in cell IGI
 biological_processGO:0060026 convergent extension IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta decreased diameter , abnormal
dorsal aorta constricted , abnormal
dorsal aorta blood vessel lumenization decreased process quality , abnormal
dorsal aorta closed , abnormal
dorsal aorta endothelial cell increased amount , abnormal
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 ZFA:0000058 polster polster mislocalised , abnormal
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 ZFA:0000132 neural plate neural plate increased width , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein endothelial cell increased amount , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line has extra parts of type posterior lateral line neuromast , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein closed , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type parachordal vessel , abnormal
whole organism forerunner cell group cellular motility , abnormal
whole organism EVL cellular motility , abnormal
whole organism YSL cellular motility , abnormal
whole organism DEL cellular motility , abnormal
whole organism cortical actin cytoskeleton disorganized , abnormal
whole organism cortical actin cytoskeleton decreased mass density , abnormal
whole organism wholly dorsalized , abnormal
whole organism decreased length , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium has extra parts of type posterior lateral line primordium cell, abnormal
posterior lateral line primordium posterior region has extra parts of type posterior lateral line primordium cell, abnormal
posterior lateral line primordium cell proliferation increased occurrence , abnormal
posterior lateral line primordium posterior lateral line neuromast primordium migration decreased speed , abnormal
posterior lateral line primordium increased distribution , abnormal
posterior lateral line primordium has number of posterior lateral line primordium cell, ameliorated
posterior lateral line primordium cell proliferation occurrence , ameliorated
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 ZFA:0001285 intersegmental vessel intersegmental vessel blood vessel endothelial cell decreased amount , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel increased amount , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature blood circulation decreased occurrence , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel aplastic , abnormal
dorsal longitudinal anastomotic vessel closed , abnormal
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 ZFA:0005314 blood vessel blood vessel unlumenized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000068401 yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*  / complex / reaction
 ENSDARG00000067719 wwtr1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / complex / reaction






 

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