ENSMUSG00000041688


Mus musculus

Features
Gene ID: ENSMUSG00000041688
  
Biological name :Amot
  
Synonyms : Amot / Angiomotin / Q8VHG2
  
Possible biological names infered from orthology : Q4VCS5
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F2
Gene start: 145446425
Gene end: 145505181
  
Corresponding Affymetrix probe sets: 10607189 (MoGene1.0st)   1425907_s_at (Mouse Genome 430 2.0 Array)   1427584_at (Mouse Genome 430 2.0 Array)   1454890_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108454
Ensembl peptide - ENSMUSP00000116189
Ensembl peptide - ENSMUSP00000117777
Ensembl peptide - ENSMUSP00000120226
Ensembl peptide - ENSMUSP00000108455
NCBI entrez gene - 27494     See in Manteia.
MGI - MGI:108440
RefSeq - XM_011247828
RefSeq - NM_001290274
RefSeq - NM_153319
RefSeq - XM_006528864
RefSeq - XM_006528867
RefSeq Peptide - NP_001277203
RefSeq Peptide - NP_695231
swissprot - F6YMV1
swissprot - B1AXE9
swissprot - Q8VHG2
swissprot - F6QYS7
swissprot - A0A067XG49
Ensembl - ENSMUSG00000041688
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 amotENSDARG00000078335Danio rerio
 AMOTENSGALG00000007952Gallus gallus
 AMOTENSG00000126016Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Amotl1 / Q9D4H4 / Angiomotin-like protein 1 / Q8IY63* / angiomotin like 1*ENSMUSG0000001307638
Amotl2 / Q8K371 / Angiomotin-like protein 2 / Q9Y2J4* / angiomotin like 2*ENSMUSG0000003253129


Protein motifs (from Interpro)
Interpro ID Name
 IPR009114  Angiomotin
 IPR024646  Angiomotin, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0003365 establishment of cell polarity involved in ameboidal cell migration IMP
 biological_processGO:0006935 chemotaxis IMP
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0034260 negative regulation of GTPase activity IMP
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0040019 positive regulation of embryonic development IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0043116 negative regulation of vascular permeability ISO
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IMP
 cellular_componentGO:0001725 stress fiber ISO
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043532 angiostatin binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Itgb6tm1Des/Itgb6tm1Des,Tg(SFTPC-ITGB6)1Des/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amottm1Bhr/Y
Genetic Background: B6.129S7-Amottm1Bhr

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011255 abnormal anterior visceral endoderm cell migration "any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue" [MGI:csmith, PMID:17078044]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Amottm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / complex / reaction
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / complex / reaction






 

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