ENSMUSG00000020849


Mus musculus

Features
Gene ID: ENSMUSG00000020849
  
Biological name :Ywhae
  
Synonyms : P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / Ywhae
  
Possible biological names infered from orthology : P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 75732869
Gene end: 75765845
  
Corresponding Affymetrix probe sets: 10378739 (MoGene1.0st)   1426384_a_at (Mouse Genome 430 2.0 Array)   1426385_x_at (Mouse Genome 430 2.0 Array)   1435702_s_at (Mouse Genome 430 2.0 Array)   1438839_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123504
Ensembl peptide - ENSMUSP00000070993
Ensembl peptide - ENSMUSP00000117877
NCBI entrez gene - 22627     See in Manteia.
MGI - MGI:894689
RefSeq - NM_009536
RefSeq Peptide - NP_033562
swissprot - Q5SS40
swissprot - D6REF3
swissprot - F6WA09
swissprot - P62259
Ensembl - ENSMUSG00000020849
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ywhae1ENSDARG00000006399Danio rerio
 YWHAEENSGALG00000002661Gallus gallus
 YWHAEENSG00000108953Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ywhaz / P63101 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideENSMUSG0000002228566
Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*ENSMUSG0000001832664
Ywhaq / P68254 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaENSMUSG0000007643263
Ywhag / P61982 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma*ENSMUSG0000005139160
Ywhah / P68510 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta*ENSMUSG0000001896560
Sfn / O70456 / stratifin / P31947*ENSMUSG0000004728158


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006605 protein targeting IDA
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035308 negative regulation of protein dephosphorylation IDA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060306 regulation of membrane repolarization IEA
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1901020 negative regulation of calcium ion transmembrane transporter activity IEA
 biological_processGO:1902309 negative regulation of peptidyl-serine dephosphorylation IEA
 biological_processGO:1905913 negative regulation of calcium ion export across plasma membrane IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005871 kinesin complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0090724 central region of growth cone IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050815 phosphoserine residue binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Signaling by Hippo
NADE modulates death signalling
Regulation of PLK1 Activity at G2/M Transition
Regulation of HSF1-mediated heat shock response
HSF1 activation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Ywhaetm1Awb/Ywhae+
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Ywhaetm1Awb/Ywhae+
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0004759 decreased mitotic index "decreased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+,Ywhaetm1Awb/Ywhae+
Genetic Background: either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0008284 abnormal hippocampus pyramidal cell layer 
Show

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ywhaetm1Awb/Ywhae+
Genetic Background: involves: 129S6/SvEvTac

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ywhaetm1Awb/Ywhae+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sema3ftm1.1Ddg/Sema3ftm1.2Ddg,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011390 abnormal fetal cardiomyocyte physiology "any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [MGI:csmith, PMID:17429040]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Gad2tm1.1Ksvo/Gad2tm1.1Ksvo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / reaction / complex
 ENSMUSG00000029518 Rab35 / Q6PHN9 / RAB35, member RAS oncogene family / Q15286*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / complex / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000035392 Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*  / complex / reaction
 ENSMUSG00000046432 Bex3 / Q9WTZ9 / Protein BEX3 / Q00994* / brain expressed X-linked 3*  / reaction / complex
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction
 ENSMUSG00000020849 Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...  / complex
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex






 

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