ENSMUSG00000018965


Mus musculus

Features
Gene ID: ENSMUSG00000018965
  
Biological name :Ywhah
  
Synonyms : P68510 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide / Ywhah
  
Possible biological names infered from orthology : Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 33018816
Gene end: 33027966
  
Corresponding Affymetrix probe sets: 10494662 (MoGene1.0st)   10521031 (MoGene1.0st)   1416004_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019109
NCBI entrez gene - 22629     See in Manteia.
MGI - MGI:109194
RefSeq - NM_011738
RefSeq Peptide - NP_035868
swissprot - P68510
Ensembl - ENSMUSG00000018965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ywhahENSDARG00000005560Danio rerio
 YWHAHENSGALG00000006743Gallus gallus
 YWHAHENSG00000128245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ywhag / P61982 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma*ENSMUSG0000005139187
Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*ENSMUSG0000001832676
Ywhaz / P63101 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideENSMUSG0000002228574
Ywhaq / P68254 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaENSMUSG0000007643270
Sfn / O70456 / stratifin / P31947*ENSMUSG0000004728163
Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...ENSMUSG0000002084962


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002028 regulation of sodium ion transport ISS
 biological_processGO:0006713 glucocorticoid catabolic process IEA
 biological_processGO:0006886 intracellular protein transport IDA
 biological_processGO:0007010 cytoskeleton organization NAS
 biological_processGO:0007088 regulation of mitotic nuclear division NAS
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IEA
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IDA
 biological_processGO:0086010 membrane depolarization during action potential ISS
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity ISS
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014704 intercalated disc IC
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017080 sodium channel regulator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IDA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018965 Ywhah / P68510 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta*  / complex






 

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