ENSMUSG00000076432


Mus musculus

Features
Gene ID: ENSMUSG00000076432
  
Biological name :Ywhaq
  
Synonyms : P68254 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta / Ywhaq
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.3
Gene start: 21390071
Gene end: 21417637
  
Corresponding Affymetrix probe sets: 10399629 (MoGene1.0st)   1420828_s_at (Mouse Genome 430 2.0 Array)   1420829_a_at (Mouse Genome 430 2.0 Array)   1420830_x_at (Mouse Genome 430 2.0 Array)   1432842_s_at (Mouse Genome 430 2.0 Array)   1436846_x_at (Mouse Genome 430 2.0 Array)   1437608_x_at (Mouse Genome 430 2.0 Array)   1460590_s_at (Mouse Genome 430 2.0 Array)   1460621_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106602
Ensembl peptide - ENSMUSP00000117118
Ensembl peptide - ENSMUSP00000123605
Ensembl peptide - ENSMUSP00000100067
NCBI entrez gene - 22630     See in Manteia.
MGI - MGI:891963
RefSeq - NM_011739
RefSeq Peptide - NP_035869
swissprot - P68254
swissprot - A3KML3
swissprot - F6VW30
swissprot - F6YY69
Ensembl - ENSMUSG00000076432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ywhaqaENSDARG00000042539Danio rerio
 ywhaqbENSDARG00000023323Danio rerio
 YWHAQENSGALG00000016433Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*ENSMUSG0000001832681
Ywhaz / P63101 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptideENSMUSG0000002228580
Ywhah / P68510 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta*ENSMUSG0000001896571
Sfn / O70456 / stratifin / P31947*ENSMUSG0000004728171
Ywhag / P61982 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma*ENSMUSG0000005139170
Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...ENSMUSG0000002084966


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IPI
 biological_processGO:0034766 negative regulation of ion transmembrane transport IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO
 molecular_functionGO:0071889 14-3-3 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: YwhaqGt(RRR746)Byg/Ywhaq+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Acacatm1Jkus/Acacatm1Jkus,Tg(Fabp1-cre)1Mmt/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000076432 Ywhaq / P68254 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta  / complex






 

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