ENSMUSG00000022285


Mus musculus

Features
Gene ID: ENSMUSG00000022285
  
Biological name :Ywhaz
  
Synonyms : P63101 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide / Ywhaz
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B3.1
Gene start: 36770770
Gene end: 36796929
  
Corresponding Affymetrix probe sets: 10428204 (MoGene1.0st)   10493891 (MoGene1.0st)   1416102_at (Mouse Genome 430 2.0 Array)   1416103_at (Mouse Genome 430 2.0 Array)   1436971_x_at (Mouse Genome 430 2.0 Array)   1436981_a_at (Mouse Genome 430 2.0 Array)   1439005_x_at (Mouse Genome 430 2.0 Array)   1448218_s_at (Mouse Genome 430 2.0 Array)   1448219_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105991
Ensembl peptide - ENSMUSP00000115928
Ensembl peptide - ENSMUSP00000153983
Ensembl peptide - ENSMUSP00000120610
Ensembl peptide - ENSMUSP00000022894
Ensembl peptide - ENSMUSP00000105988
Ensembl peptide - ENSMUSP00000105990
NCBI entrez gene - 22631     See in Manteia.
MGI - MGI:109484
RefSeq - NM_001253807
RefSeq - XM_011245352
RefSeq - NM_011740
RefSeq - NM_001253805
RefSeq - NM_001253806
RefSeq Peptide - NP_001240734
RefSeq Peptide - NP_001240735
RefSeq Peptide - NP_001240736
RefSeq Peptide - NP_001343498
RefSeq Peptide - NP_035870
swissprot - D3YW45
swissprot - D3YXN6
swissprot - P63101
swissprot - D3YXF4
Ensembl - ENSMUSG00000022285
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 YWHAZENSGALG00000031387Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*ENSMUSG0000001832687
Ywhaq / P68254 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaENSMUSG0000007643280
Ywhag / P61982 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma*ENSMUSG0000005139175
Ywhah / P68510 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta*ENSMUSG0000001896574
Sfn / O70456 / stratifin / P31947*ENSMUSG0000004728171
Ywhae / P62259 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation prote...ENSMUSG0000002084969


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IDA
 biological_processGO:0010941 regulation of cell death IGI
 biological_processGO:0051683 establishment of Golgi localization ISO
 biological_processGO:0090168 Golgi reassembly ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

Allelic Composition: Ywhaztm1b(EUCOMM)Hmgu/Ywhaztm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Ywhaztm1b(EUCOMM)Hmgu/Tcp

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0009938 abnormal hippocampus granule cell morphology "any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0010011 ectopic hippocampus pyramidal cells "the hippocampus pyramidal cell body resides in places other than the pyramidal cell layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

Allelic Composition: YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
Genetic Background: either: B6.129S5-YwhazGt(OST432062)Lex or C.129S5-YwhazGt(OST432062)Lex or (involves: 129S5/SvEvBrd * 129T2/SvEmsWehi))

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022285 Ywhaz / P63101 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide  / complex






 

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