ENSGALG00000031387


Gallus gallus

Features
Gene ID: ENSGALG00000031387
  
Biological name :YWHAZ
  
Synonyms : 14-3-3 protein zeta / Q5ZKC9 / YWHAZ
  
Possible biological names infered from orthology : P63101 / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 129241561
Gene end: 129267480
  
Corresponding Affymetrix probe sets: Gga.14108.1.A1_at (Chicken Array)   Gga.14108.1.S1_at (Chicken Array)   Gga.4784.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049152
Ensembl peptide - ENSGALP00000064772
Ensembl peptide - ENSGALP00000064729
Ensembl peptide - ENSGALP00000061765
Ensembl peptide - ENSGALP00000061526
Ensembl peptide - ENSGALP00000048283
NCBI entrez gene - 425619     See in Manteia.
RefSeq - NM_001031343
RefSeq Peptide - NP_001026514
swissprot - A0A1L1RRT9
swissprot - A0A1L1S0W4
swissprot - Q5ZKC9
swissprot - A0A1D5P8V3
swissprot - A0A1L1RSI2
Ensembl - ENSGALG00000031387
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 YWHAZENSG00000164924Homo sapiens
 YwhazENSMUSG00000022285Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAB / Q5ZLQ6 / 14-3-3 protein beta/alpha / Q9CQV8* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta* / tyrosine 3-monooxygenase/tryptophan 5-monoox...ENSGALG0000000414387
YWHAH / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta / P68510* / Q04917* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide*ENSGALG0000000674376
YWHAQ / Q5ZMD1 / 14-3-3 protein theta / P68254* / P27348* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta*ENSGALG0000001643375
YWHAG / 14-3-3 protein gamma / P61982* / P61981* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activ...ENSGALG0000001735875
SFN / stratifin / O70456* / P31947*ENSGALG0000002811571
YWHAE / Q5ZMT0 / 14-3-3 protein epsilon / P62259* / P62258* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon* / tyrosine 3-monooxygenase/tryptophan 5-monoox...ENSGALG0000000266169


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0010941 regulation of cell death IEA
 biological_processGO:0051683 establishment of Golgi localization IEA
 biological_processGO:0090168 Golgi reassembly IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Deactivation of the beta-catenin transactivating complex
Rap1 signalling
GP1b-IX-V activation signalling
KSRP (KHSRP) binds and destabilizes mRNA
Interleukin-3, Interleukin-5 and GM-CSF signaling
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012218 CBY1 / chibby family member 1, beta catenin antagonist / 1 * / Q9D1C2* / Q9Y3M2*  / complex / reaction
 ENSGALG00000019147 IL3RA* / P26951* / P26952* / P15509* / Q00941* / CSF2RA* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimul...  / reaction / complex
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSGALG00000016693 CSF2RA / IL3RA* / P15509* / Q00941* / P26951* / P26952* / interleukin 3 receptor subunit alpha* / colony stimulating factor 2 receptor alpha subunit* / Granulocyte-macrophage colony-stimula...  / reaction / complex
 ENSGALG00000008267 IL5RA / interleukin 5 receptor subunit alpha / P21183* / Q01344*  / reaction / complex
 ENSGALG00000033885 RAP1GAP2 / rap1 GTPase-activating protein 2 / Q5SVL6* / Q684P5*  / reaction / complex
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / reaction / complex
 ENSGALG00000021529 GP1BB / glycoprotein Ib platelet beta subunit / P13224* / P56400* / glycoprotein Ib, beta polypeptide*  / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000002583 PIK3CD / phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / O00329* / O35904* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / reaction / complex
 ENSGALG00000045125 GP5 / glycoprotein V platelet / P40197*  / complex
 ENSGALG00000004998 RAF1 / P05625 / RAF proto-oncogene serine/threonine-protein kinase / Q99N57* / P04049* / Raf-1 proto-oncogene, serine/threonine kinase* / Mus musculus v-raf-leukemia viral onco 1 (Raf1), t...  / reaction / complex
 ENSGALG00000031387 YWHAZ / Q5ZKC9 / 14-3-3 protein zeta / P63104* / P63101* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenas...  / complex
 ENSGALG00000029476 XPO1 / exportin 1 / O14980* / Q6P5F9*  / reaction / complex






 

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