ENSG00000128245


Homo sapiens

Features
Gene ID: ENSG00000128245
  
Biological name :YWHAH
  
Synonyms : Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta / YWHAH
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q12.3
Gene start: 31944461
Gene end: 31957603
  
Corresponding Affymetrix probe sets: 201020_at (Human Genome U133 Plus 2.0 Array)   236559_at (Human Genome U133 Plus 2.0 Array)   242325_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000248975
Ensembl peptide - ENSP00000408468
Ensembl peptide - ENSP00000406747
Ensembl peptide - ENSP00000380629
NCBI entrez gene - 7533     See in Manteia.
OMIM - 113508
RefSeq - NM_003405
RefSeq Peptide - NP_003396
swissprot - A0A024R1K7
swissprot - A2IDB2
swissprot - Q04917
swissprot - F8WEB6
swissprot - A2IDB1
Ensembl - ENSG00000128245
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ywhahENSDARG00000005560Danio rerio
 YWHAHENSGALG00000006743Gallus gallus
 YwhahENSMUSG00000018965Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAG / P61981 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gammaENSG0000017002787
YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaENSG0000016691375
YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetaENSG0000016492474
YWHAQ / P27348 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaENSG0000013430870
SFN / P31947 / stratifinENSG0000017579363
YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonENSG0000010895362


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002028 regulation of sodium ion transport IDA
 biological_processGO:0006713 glucocorticoid catabolic process IDA
 biological_processGO:0006886 intracellular protein transport ISS
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IDA
 biological_processGO:0045664 regulation of neuron differentiation ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048167 regulation of synaptic plasticity ISS
 biological_processGO:0050774 negative regulation of dendrite morphogenesis ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0086010 membrane depolarization during action potential IDA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0014704 intercalated disc IC
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017080 sodium channel regulator activity IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128245 YWHAH / Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta  / complex






 

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