ENSG00000175793


Homo sapiens

Features
Gene ID: ENSG00000175793
  
Biological name :SFN
  
Synonyms : P31947 / SFN / stratifin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.11
Gene start: 26863138
Gene end: 26864457
  
Corresponding Affymetrix probe sets: 209260_at (Human Genome U133 Plus 2.0 Array)   33322_i_at (Human Genome U133 Plus 2.0 Array)   33323_r_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340989
NCBI entrez gene - 2810     See in Manteia.
OMIM - 601290
RefSeq - NM_006142
RefSeq Peptide - NP_006133
swissprot - P31947
Ensembl - ENSG00000175793
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ywhaqaENSDARG00000042539Danio rerio
 ywhaqbENSDARG00000023323Danio rerio
 SFNENSGALG00000028115Gallus gallus
 SfnENSMUSG00000047281Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zetaENSG0000016492470
YWHAQ / P27348 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein thetaENSG0000013430869
YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaENSG0000016691366
YWHAG / P61981 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gammaENSG0000017002764
YWHAH / Q04917 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein etaENSG0000012824562
YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilonENSG0000010895360


Protein motifs (from Interpro)
Interpro ID Name
 IPR000308  14-3-3 protein
 IPR023409  14-3-3 protein, conserved site
 IPR023410  14-3-3 domain
 IPR036815  14-3-3 domain superfamily
 IPR037435  14-3-3 protein sigma


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IDA
 biological_processGO:0003334 keratinocyte development IEA
 biological_processGO:0006469 negative regulation of protein kinase activity TAS
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:0010482 regulation of epidermal cell division IEA
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0045606 positive regulation of epidermal cell differentiation IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0061436 establishment of skin barrier IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008426 protein kinase C inhibitor activity TAS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087088 BAX / Q07812 / BCL2 associated X, apoptosis regulator  / complex / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / complex / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / complex / reaction
 ENSG00000175793 SFN / P31947 / stratifin  / reaction / complex






 

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