ENSMUSG00000024812


Mus musculus

Features
Gene ID: ENSMUSG00000024812
  
Biological name :Tjp2
  
Synonyms : Q9Z0U1 / Tight junction protein ZO-2 / Tjp2
  
Possible biological names infered from orthology : AL358113.1 / Q9UDY2 / tight junction protein 2
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: B
Gene start: 24094523
Gene end: 24225026
  
Corresponding Affymetrix probe sets: 10466745 (MoGene1.0st)   1434599_a_at (Mouse Genome 430 2.0 Array)   1434600_at (Mouse Genome 430 2.0 Array)   1450984_at (Mouse Genome 430 2.0 Array)   1450985_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097154
NCBI entrez gene - 21873     See in Manteia.
MGI - MGI:1341872
RefSeq - XM_017318137
RefSeq - NM_001198985
RefSeq - NM_011597
RefSeq - XM_006526909
RefSeq - XM_011247219
RefSeq - XM_017318136
RefSeq - XM_006526904
RefSeq - XM_006526905
RefSeq - XM_006526907
RefSeq - XM_006526908
RefSeq Peptide - NP_035727
RefSeq Peptide - NP_001185914
swissprot - Q9Z0U1
Ensembl - ENSMUSG00000024812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tjp2aENSDARG00000063309Danio rerio
 tjp2bENSDARG00000023443Danio rerio
 TJP2ENSGALG00000015109Gallus gallus
 AL358113.1ENSG00000285130Homo sapiens
 TJP2ENSG00000119139Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tjp1 / P39447 / tight junction protein 1 / Q07157*ENSMUSG0000003051647
Tjp3 / tight junction protein 3 / O95049*ENSMUSG0000003491733
Dlg5 / E9Q9R9 / Disks large homolog 5 / Q8TDM6* / discs large MAGUK scaffold protein 5*ENSMUSG0000002178218
Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*ENSMUSG0000005257214
Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*ENSMUSG0000000088114
Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*ENSMUSG0000002088613
Dlg1 / Q811D0 / Disks large homolog 1 / Q12959* / discs large MAGUK scaffold protein 1*ENSMUSG0000002277013
Mpp7 / MAGUK p55 subfamily member 7 isoform 2 / Q5T2T1* / membrane palmitoylated protein 7*ENSMUSG0000005744010
Mpp3 / membrane palmitoylated protein 3 / Q13368*ENSMUSG0000005237310
Mpp5 / Q9JLB2 / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) / Q8N3R9* / membrane palmitoylated protein 5*ENSMUSG000000211129
Mpp4 / Q6P7F1 / MAGUK p55 subfamily member 4 / Q96JB8* / membrane palmitoylated protein 4*ENSMUSG000000795509
Mpp2 / Q9WV34 / Mus musculus membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (Mpp2), transcript variant 1, mRNA. / Q14168* / membrane palmitoylated protein 2*ENSMUSG000000173149
Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*ENSMUSG000000310129
Mpp6 / Q9JLB0 / membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) / Q9NZW5* / membrane palmitoylated protein 6*ENSMUSG000000383888
Mpp1 / P70290 / membrane protein, palmitoylated / Q00013* / membrane palmitoylated protein 1*ENSMUSG000000314027
Guk1 / guanylate kinase 1 / Q16774*ENSMUSG000000204443


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR005417  Tight junction protein ZO
 IPR005419  Tight junction protein ZO-2
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035598  ZO-2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0050892 intestinal absorption ISO
 biological_processGO:0071847 TNFSF11-mediated signaling pathway IMP
 biological_processGO:0090557 establishment of endothelial intestinal barrier ISO
 biological_processGO:0090559 regulation of membrane permeability ISO
 biological_processGO:2001205 negative regulation of osteoclast development IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005921 gap junction ISO
 cellular_componentGO:0005923 bicellular tight junction ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0070160 occluding junction IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0030674 protein binding, bridging ISO
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Signaling by Hippo
Apoptotic cleavage of cell adhesion proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0003950 abnormal plasma membrane morphology "anomalous structure of the semipermeable membrane that encloses the cytoplasm of a cell" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Pmp22Tr-J/Pmp22+
Genetic Background: B6.Cg-Pmp22Tr-J Krt25Re/+ +/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / reaction / complex
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / complex / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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