ENSMUSG00000052373


Mus musculus

Features
Gene ID: ENSMUSG00000052373
  
Biological name :Mpp3
  
Synonyms : membrane palmitoylated protein 3 / Mpp3
  
Possible biological names infered from orthology : Q13368
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 101999652
Gene end: 102028461
  
Corresponding Affymetrix probe sets: 10391518 (MoGene1.0st)   1419077_at (Mouse Genome 430 2.0 Array)   1459611_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102786
Ensembl peptide - ENSMUSP00000055469
Ensembl peptide - ENSMUSP00000097969
Ensembl peptide - ENSMUSP00000102785
NCBI entrez gene - 13384     See in Manteia.
MGI - MGI:1328354
RefSeq - XM_006532139
RefSeq - XM_006532140
RefSeq - NM_007863
RefSeq - XM_006532138
RefSeq Peptide - NP_031889
swissprot - Q6XE40
swissprot - B1AQF7
Ensembl - ENSMUSG00000052373
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpp3aENSDARG00000015184Danio rerio
 mpp3bENSDARG00000062667Danio rerio
 MPP3ENSGALG00000042521Gallus gallus
 MPP3ENSG00000161647Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mpp7 / MAGUK p55 subfamily member 7 isoform 2 / Q5T2T1* / membrane palmitoylated protein 7*ENSMUSG0000005744053
Mpp4 / Q6P7F1 / MAGUK p55 subfamily member 4 / Q96JB8* / membrane palmitoylated protein 4*ENSMUSG0000007955039
Mpp5 / Q9JLB2 / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) / Q8N3R9* / membrane palmitoylated protein 5*ENSMUSG0000002111232
Mpp6 / Q9JLB0 / membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) / Q9NZW5* / membrane palmitoylated protein 6*ENSMUSG0000003838831
Mpp2 / Q9WV34 / Mus musculus membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (Mpp2), transcript variant 1, mRNA. / Q14168* / membrane palmitoylated protein 2*ENSMUSG0000001731431
Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*ENSMUSG0000003101228
Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*ENSMUSG0000000088126
Dlg1 / Q811D0 / Disks large homolog 1 / Q12959* / discs large MAGUK scaffold protein 1*ENSMUSG0000002277025
Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*ENSMUSG0000005257225
Mpp1 / P70290 / membrane protein, palmitoylated / Q00013* / membrane palmitoylated protein 1*ENSMUSG0000003140224
Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*ENSMUSG0000002088623
Dlg5 / E9Q9R9 / Disks large homolog 5 / Q8TDM6* / discs large MAGUK scaffold protein 5*ENSMUSG0000002178222
Tjp2 / Q9Z0U1 / Tight junction protein ZO-2 / Q9UDY2* / AL358113.1* / tight junction protein 2*ENSMUSG0000002481220
Tjp1 / P39447 / tight junction protein 1 / Q07157*ENSMUSG0000003051619
Tjp3 / tight junction protein 3 / O95049*ENSMUSG0000003491719
Guk1 / guanylate kinase 1 / Q16774*ENSMUSG0000002044412


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR004172  L27 domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR014775  L27 domain, C-terminal
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035604  MPP3, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily
 IPR036892  L27 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030165 PDZ domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0,Tg(RNU6-RNAi:Mpp5)13Wij/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL

 MP:0003732 abnormal outer plexiform layer morphology "malformation/anomalous structure of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

 MP:0010236 abnormal retina outer limiting membrane morphology "any structural anomaly of the row of junctional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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