ENSMUSG00000052572


Mus musculus

Features
Gene ID: ENSMUSG00000052572
  
Biological name :Dlg2
  
Synonyms : Disks large homolog 2 / Dlg2 / Q91XM9
  
Possible biological names infered from orthology : discs large MAGUK scaffold protein 2 / Q15700
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 91090706
Gene end: 92449247
  
Corresponding Affymetrix probe sets: 10554900 (MoGene1.0st)   1421199_at (Mouse Genome 430 2.0 Array)   1421200_at (Mouse Genome 430 2.0 Array)   1437927_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102811
Ensembl peptide - ENSMUSP00000102814
Ensembl peptide - ENSMUSP00000073885
Ensembl peptide - ENSMUSP00000095910
NCBI entrez gene - 23859     See in Manteia.
MGI - MGI:1344351
RefSeq - XM_017322227
RefSeq - XM_006507785
RefSeq - XM_006507786
RefSeq - XM_006507787
RefSeq - XM_006507788
RefSeq - XM_006507789
RefSeq - XM_011241786
RefSeq - NM_001243046
RefSeq - NM_011807
RefSeq - XM_006507767
RefSeq - XM_006507768
RefSeq - XM_006507769
RefSeq - XM_006507770
RefSeq - XM_006507771
RefSeq - XM_006507772
RefSeq - XM_006507773
RefSeq - XM_006507776
RefSeq - XM_006507777
RefSeq - XM_006507778
RefSeq - XM_006507779
RefSeq - XM_006507780
RefSeq - XM_006507781
RefSeq - XM_006507782
RefSeq - XM_006507783
RefSeq - XM_006507784
RefSeq Peptide - NP_001229975
RefSeq Peptide - NP_035937
swissprot - E9Q2L2
swissprot - D3YWU0
swissprot - Q91XM9
swissprot - D3YUZ8
Ensembl - ENSMUSG00000052572
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlg2ENSDARG00000099323Danio rerio
 ENSGALG00000041225Gallus gallus
 DLG2ENSG00000150672Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dlg1 / Q811D0 / Disks large homolog 1 / Q12959* / discs large MAGUK scaffold protein 1*ENSMUSG0000002277070
Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*ENSMUSG0000000088164
Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*ENSMUSG0000002088660
Dlg5 / E9Q9R9 / Disks large homolog 5 / Q8TDM6* / discs large MAGUK scaffold protein 5*ENSMUSG0000002178222
Mpp5 / Q9JLB2 / membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) / Q8N3R9* / membrane palmitoylated protein 5*ENSMUSG0000002111220
Tjp3 / tight junction protein 3 / O95049*ENSMUSG0000003491720
Tjp1 / P39447 / tight junction protein 1 / Q07157*ENSMUSG0000003051619
Tjp2 / Q9Z0U1 / Tight junction protein ZO-2 / Q9UDY2* / AL358113.1* / tight junction protein 2*ENSMUSG0000002481219
Mpp7 / MAGUK p55 subfamily member 7 isoform 2 / Q5T2T1* / membrane palmitoylated protein 7*ENSMUSG0000005744018
Mpp4 / Q6P7F1 / MAGUK p55 subfamily member 4 / Q96JB8* / membrane palmitoylated protein 4*ENSMUSG0000007955018
Mpp2 / Q9WV34 / Mus musculus membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (Mpp2), transcript variant 1, mRNA. / Q14168* / membrane palmitoylated protein 2*ENSMUSG0000001731418
Mpp3 / membrane palmitoylated protein 3 / Q13368*ENSMUSG0000005237317
Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*ENSMUSG0000003101217
Mpp6 / Q9JLB0 / membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) / Q9NZW5* / membrane palmitoylated protein 6*ENSMUSG0000003838817
Mpp1 / P70290 / membrane protein, palmitoylated / Q00013* / membrane palmitoylated protein 1*ENSMUSG0000003140214
Guk1 / guanylate kinase 1 / Q16774*ENSMUSG000000204448


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001478  PDZ domain
 IPR008144  Guanylate kinase-like domain
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR016313  Disks large 1-like
 IPR019583  PDZ-associated domain of NMDA receptors
 IPR019590  Disks large homologue 1, N-terminal PEST domain
 IPR020590  Guanylate kinase, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035759  Disks Large homologue 2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0010923 negative regulation of phosphatase activity IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0043113 receptor clustering IBA
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0097120 receptor localization to synapse IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IBA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044224 juxtaparanode region of axon ISO
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0004385 guanylate kinase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IBA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / complex / reaction
 ENSMUSG00000037541 Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*  / complex
 ENSMUSG00000003279 Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*  / complex
 ENSMUSG00000047495 Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*  / complex
 ENSMUSG00000031302 Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*  / complex
 ENSMUSG00000063887 Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*  / complex
 ENSMUSG00000061689 B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*  / complex
 ENSMUSG00000042388 Dlgap3 / Q6PFD5 / Disks large-associated protein 3 / O95886* / DLG associated protein 3*  / complex
 ENSMUSG00000051790 Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*  / complex
 ENSMUSG00000038738 D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*  / complex






 

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