ENSMUSG00000063887


Mus musculus

Features
Gene ID: ENSMUSG00000063887
  
Biological name :Nlgn1
  
Synonyms : Neuroligin-1 / Nlgn1 / Q99K10
  
Possible biological names infered from orthology : Q8N2Q7
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A3
Gene start: 25426215
Gene end: 26332460
  
Corresponding Affymetrix probe sets: 10497505 (MoGene1.0st)   1437160_at (Mouse Genome 430 2.0 Array)   1440630_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074565
Ensembl peptide - ENSMUSP00000103944
Ensembl peptide - ENSMUSP00000142086
Ensembl peptide - ENSMUSP00000142200
NCBI entrez gene - 192167     See in Manteia.
MGI - MGI:2179435
RefSeq - XM_017319496
RefSeq - NM_001163387
RefSeq - NM_138666
RefSeq - XM_006535425
RefSeq - XM_011249667
RefSeq - XM_017319494
RefSeq - XM_017319495
RefSeq - XM_006535415
RefSeq - XM_006535416
RefSeq - XM_006535418
RefSeq - XM_006535419
RefSeq - XM_006535420
RefSeq - XM_006535421
RefSeq - XM_006535422
RefSeq - XM_006535423
RefSeq - XM_006535424
RefSeq Peptide - NP_001156859
RefSeq Peptide - NP_619607
swissprot - Q99K10
swissprot - E9QK34
Ensembl - ENSMUSG00000063887
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlgn1ENSDARG00000077710Danio rerio
 NLGN1ENSGALG00000040938Gallus gallus
 NLGN1ENSG00000169760Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*ENSMUSG0000003130269
Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*ENSMUSG0000005179064
Ache / P21836 / acetylcholinesterase / P22303* / acetylcholinesterase (Cartwright blood group)*ENSMUSG0000002332824
Cel / Q64285 / Bile salt-activated lipase / carboxyl ester lipase*ENSMUSG0000002681823
Bche / Q03311 / Cholinesterase / P06276* / butyrylcholinesterase*ENSMUSG0000002779223
Ces2g / carboxylesterase 2G / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003187722
Ces2h / carboxylesterase 2H / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000009181322
Ces1b / carboxylesterase 1BENSMUSG0000007896422
Ces5a / Q6AW46 / Carboxylesterase 5A / Q6NT32*ENSMUSG0000005801921
Ces1g / Q8VCC2 / Liver carboxylesterase 1 ENSMUSG0000005707421
Ces1e / Q64176 / Carboxylesterase 1E ENSMUSG0000006195921
Ces2a / Q8QZR3 / Pyrethroid hydrolase Ces2a / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000005573021
Ces1a / carboxylesterase 1A / CES1* / P23141* / carboxylesterase 1*ENSMUSG0000007104721
Ces1h / carboxylesterase 1HENSMUSG0000007415621
Ces2e / Q8BK48 / Pyrethroid hydrolase Ces2e / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000003188621
Ces3b / Q8VCU1 / Carboxylesterase 3B / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006218121
Ces2c / Q91WG0 / Acylcarnitine hydrolase / CES2* / O00748* / carboxylesterase 2*ENSMUSG0000006182521
Ces3a / Q63880 / Carboxylesterase 3A / CES3* / Q6UWW8* / carboxylesterase 3*ENSMUSG0000006992221
Ces4a / Q8R0W5 / Carboxylesterase 4A / Q5XG92*ENSMUSG0000006056021
Ces1f / Q91WU0 / Carboxylesterase 1F ENSMUSG0000003172521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000460  Neuroligin
 IPR002018  Carboxylesterase, type B
 IPR019819  Carboxylesterase type B, conserved site
 IPR029058  Alpha/Beta hydrolase fold
 IPR030022  Neuroligin-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IGI
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007158 neuron cell-cell adhesion IDA
 biological_processGO:0007399 nervous system development IDA
 biological_processGO:0007416 synapse assembly IDA
 biological_processGO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness IMP
 biological_processGO:0016080 synaptic vesicle targeting IMP
 biological_processGO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
 biological_processGO:0031175 neuron projection development ISO
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic ISS
 biological_processGO:0035418 protein localization to synapse IDA
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045664 regulation of neuron differentiation IDA
 biological_processGO:0048489 synaptic vesicle transport IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048789 cytoskeletal matrix organization at active zone IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IGI
 biological_processGO:0050808 synapse organization ISO
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0051491 positive regulation of filopodium assembly ISS
 biological_processGO:0051965 positive regulation of synapse assembly ISS
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060999 positive regulation of dendritic spine development ISS
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis ISO
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0072553 terminal button organization IMP
 biological_processGO:0097091 synaptic vesicle clustering IDA
 biological_processGO:0097104 postsynaptic membrane assembly IDA
 biological_processGO:0097105 presynaptic membrane assembly IDA
 biological_processGO:0097113 AMPA glutamate receptor clustering IDA
 biological_processGO:0097114 NMDA glutamate receptor clustering ISS
 biological_processGO:0097115 neurexin clustering involved in presynaptic membrane assembly IDA
 biological_processGO:0097119 postsynaptic density protein 95 clustering IDA
 biological_processGO:0097120 receptor localization to synapse IDA
 biological_processGO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex IEA
 biological_processGO:0099560 synaptic membrane adhesion IMP
 biological_processGO:0140058 neuron projection arborization IEA
 biological_processGO:1900029 positive regulation of ruffle assembly IEA
 biological_processGO:1900244 positive regulation of synaptic vesicle endocytosis IMP
 biological_processGO:1902474 positive regulation of protein localization to synapse IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction IEA
 biological_processGO:1904861 excitatory synapse assembly IMP
 biological_processGO:1905520 positive regulation of presynaptic active zone assembly IEA
 biological_processGO:2000302 positive regulation of synaptic vesicle exocytosis IMP
 biological_processGO:2000310 regulation of NMDA receptor activity ISO
 biological_processGO:2000311 regulation of AMPA receptor activity ISS
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential ISO
 biological_processGO:2000809 positive regulation of synaptic vesicle clustering IDA
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0032433 filopodium tip ISS
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060076 excitatory synapse IC
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding ISO
 molecular_functionGO:0042043 neurexin family protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity ISS
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IBA
 molecular_functionGO:0097110 scaffold protein binding ISO


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Pou3f4tm1Tno/Pou3f4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nlgn1tm1Bros/Nlgn1tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0002068 abnormal parental behavior "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4tm1Tno/Pou3f4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nlgn1tm1Bros/Nlgn1tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insl5tm1Dgen/Insl5tm1Dgen
Genetic Background: B6.129-Insl5tm1Dgen/J

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pou3f4tm1Tno/Pou3f4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nlgn1tm1Bros/Nlgn1tm1Bros,Nlgn2tm1Bros/Nlgn2tm1Bros
Genetic Background: Not Specified

Allelic Composition: Nlgn1tm1Bros/Nlgn1tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Grm6nob7/Grm6nob7
Genetic Background: C57BL/6J-Grm6nob7

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nlgn2tm1Bros/Nlgn2tm1Bros,Nlgn3tm1Bros/Nlgn3tm1Bros
Genetic Background: Not Specified

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
Show

Allelic Composition: Grm6nob7/Grm6nob7
Genetic Background: C57BL/6J-Grm6nob7

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000881 Dlg3 / P70175 / Disks large homolog 3 / Q92796* / discs large MAGUK scaffold protein 3*  / complex
 ENSMUSG00000020476 Dbnl / Q62418 / Drebrin-like protein / Q9UJU6* / drebrin like*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex
 ENSMUSG00000031012 Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*  / reaction / complex
 ENSMUSG00000019978 O70318 / Epb41l2 / Mus musculus erythrocyte membrane protein band 4.1 like 2 (Epb41l2), transcript variant 3, mRNA. / O43491* / erythrocyte membrane protein band 4.1 like 2*  / reaction / complex
 ENSMUSG00000061689 B1AZP2 / Dlgap4 / Disks large-associated protein 4 / Q9Y2H0* / DLG associated protein 4*  / complex
 ENSMUSG00000047495 Dlgap2 / Q8BJ42 / Disks large-associated protein 2 / Q9P1A6* / DLG associated protein 2*  / complex
 ENSMUSG00000003279 Dlgap1 / Q9D415 / Mus musculus DLG associated protein 1 (Dlgap1), transcript variant 6, mRNA. / O14490* / DLG associated protein 1*  / complex
 ENSMUSG00000028906 Epb41 / P48193 / erythrocyte membrane protein band 4.1 / P11171*  / complex / reaction
 ENSMUSG00000024044 Q9WV92 / Epb41l3 / Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed / Q9Y2J2* / erythrocyte membrane protein band 4.1 like 3*  / reaction / complex
 ENSMUSG00000026383 Q8BGS1 / Epb41l5 / Band 4.1-like protein 5 / Q9HCM4* / erythrocyte membrane protein band 4.1 like 5*  / reaction / complex
 ENSMUSG00000063887 Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*  / complex
 ENSMUSG00000042388 Dlgap3 / Q6PFD5 / Disks large-associated protein 3 / O95886* / DLG associated protein 3*  / complex
 ENSMUSG00000037541 Q80Z38 / Shank2 / SH3 and multiple ankyrin repeat domains protein 2 / Q9UPX8* / SH3 and multiple ankyrin repeat domains 2*  / complex
 ENSMUSG00000052572 Dlg2 / Q91XM9 / Disks large homolog 2 / Q15700* / discs large MAGUK scaffold protein 2*  / complex
 ENSMUSG00000038738 D3YZU1 / Shank1 / SH3 and multiple ankyrin repeat domains protein 1 / Q9Y566* / SH3 and multiple ankyrin repeat domains 1*  / complex






 

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