ENSMUSG00000026383


Mus musculus

Features
Gene ID: ENSMUSG00000026383
  
Biological name :Epb41l5
  
Synonyms : Band 4.1-like protein 5 / Epb41l5 / Q8BGS1
  
Possible biological names infered from orthology : erythrocyte membrane protein band 4.1 like 5 / Q9HCM4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 119545037
Gene end: 119649000
  
Corresponding Affymetrix probe sets: 10357164 (MoGene1.0st)   1425199_a_at (Mouse Genome 430 2.0 Array)   1439284_at (Mouse Genome 430 2.0 Array)   1455861_at (Mouse Genome 430 2.0 Array)   1459120_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058966
Ensembl peptide - ENSMUSP00000139683
Ensembl peptide - ENSMUSP00000140227
Ensembl peptide - ENSMUSP00000027632
Ensembl peptide - ENSMUSP00000128374
NCBI entrez gene - 226352     See in Manteia.
MGI - MGI:103006
RefSeq - XM_006529400
RefSeq - NM_001113416
RefSeq - NM_145506
RefSeq - XM_006529397
RefSeq - XM_006529398
RefSeq - XM_006529399
RefSeq Peptide - NP_001106887
RefSeq Peptide - NP_663481
swissprot - A0A087WP93
swissprot - Q8BGS1
Ensembl - ENSMUSG00000026383
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epb41l5ENSDARG00000032324Danio rerio
 EPB41L5ENSGALG00000011605Gallus gallus
 Q9HCM4ENSG00000115109Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JMC8 / Epb41l4b / Band 4.1-like protein 4B / Q9H329* / erythrocyte membrane protein band 4.1 like 4B*ENSMUSG0000002843441
O70318 / Epb41l2 / Mus musculus erythrocyte membrane protein band 4.1 like 2 (Epb41l2), transcript variant 3, mRNA. / O43491* / erythrocyte membrane protein band 4.1 like 2*ENSMUSG0000001997827
Q9WV92 / Epb41l3 / Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed / Q9Y2J2* / erythrocyte membrane protein band 4.1 like 3*ENSMUSG0000002404426
Epb41 / P48193 / erythrocyte membrane protein band 4.1 / P11171*ENSMUSG0000002890625
Epb41l1 / band 4.1-like protein 1 isoform d / Q9H4G0* / erythrocyte membrane protein band 4.1 like 1*ENSMUSG0000002762425
Ptpn4 / Q9WU22 / Tyrosine-protein phosphatase non-receptor type 4 / P29074* / protein tyrosine phosphatase, non-receptor type 4*ENSMUSG0000002638424
P52963 / Epb41l4a / Band 4.1-like protein 4A / Q9HCS5* / erythrocyte membrane protein band 4.1 like 4A*ENSMUSG0000002437623
Frmd3 / Q8BHD4 / FERM domain-containing protein 3 / A2A2Y4* / FERM domain containing 3*ENSMUSG0000004912222
Frmd5 / Q6P5H6 / FERM domain-containing protein 5 / Q7Z6J6* / FERM domain containing 5*ENSMUSG0000002723821
Ptpn3 / A2ALK8 / protein tyrosine phosphatase, non-receptor type 3 / P26045*ENSMUSG0000003876418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR030694  Band 4.1-like protein 5
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000904 cell morphogenesis involved in differentiation IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0001839 neural plate morphogenesis IMP
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IMP
 biological_processGO:0003382 epithelial cell morphogenesis IMP
 biological_processGO:0003383 apical constriction IDA
 biological_processGO:0006931 substrate-dependent cell migration, cell attachment to substrate IMP
 biological_processGO:0007398 ectoderm development IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0007509 mesoderm migration involved in gastrulation IMP
 biological_processGO:0009826 unidimensional cell growth IDA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0022408 negative regulation of cell-cell adhesion IMP
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0031032 actomyosin structure organization IDA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032525 somite rostral/caudal axis specification IMP
 biological_processGO:0048318 axial mesoderm development IMP
 biological_processGO:0048319 axial mesoderm morphogenesis IMP
 biological_processGO:0048339 paraxial mesoderm development IMP
 biological_processGO:0048617 embryonic foregut morphogenesis IMP
 biological_processGO:0051894 positive regulation of focal adhesion assembly IMP
 biological_processGO:0070201 regulation of establishment of protein localization IDA
 biological_processGO:0070986 left/right axis specification IMP
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0032587 ruffle membrane IDA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5tm1Sia/Epb41l5tm1Sia
Genetic Background: Not Specified

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5tm1Sia/Epb41l5tm1Sia
Genetic Background: Not Specified

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Epb41l5Gt(XC282)Byg/Epb41l5lulu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: Epb41l5Gt(XC282)Byg/Epb41l5lulu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Epb41l5tm1Sia/Epb41l5tm1Sia
Genetic Background: Not Specified

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Epb41l5Gt(XC282)Byg/Epb41l5lulu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Epb41l5Gt(AE0088)Wtsi/Epb41l5Gt(AE0088)Wtsi
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5Gt(XC282)Byg/Epb41l5lulu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm1(UBC-UBB)Rrk/Y,Ubctm1Rrk/Ubctm1Rrk
Genetic Background: involves: 129 * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1(UBC-UBB)Rrk/Y,Ubctm1Rrk/Ubctm1Rrk
Genetic Background: involves: 129 * C57BL/6J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epb41l5Gt(XC282)Byg/Epb41l5lulu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epb41l5Gt(AE0088)Wtsi/Epb41l5Gt(AE0088)Wtsi
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epb41l5Gt(AE0088)Wtsi/Epb41l5Gt(AE0088)Wtsi
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5Gt(AE0088)Wtsi/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Elmod1tm1a(EUCOMM)Hmgu/Elmod1tm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Elmod1tm1a(EUCOMM)Hmgu/H

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5tm1Sia/Epb41l5tm1Sia
Genetic Background: Not Specified

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Epb41l5tm1Sia/Epb41l5tm1Sia
Genetic Background: Not Specified

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Epb41l5Gt(AE0088)Wtsi/Epb41l5Gt(AE0088)Wtsi
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5tm1Sia/Epb41l5tm1Sia
Genetic Background: Not Specified

 MP:0006206 embryonic lethality before turning of embryo "death anytime after somite formation but before embryo turning (E8 to less than E9)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epb41l5Gt(AE0088)Wtsi/Epb41l5Gt(AE0088)Wtsi
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5Gt(AE0088)Wtsi/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epb41l5Gt(AE0088)Wtsi/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

Allelic Composition: Epb41l5tm1Sia/Epb41l5tm1Sia
Genetic Background: Not Specified

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Epb41l5Gt(XC282)Byg/Epb41l5lulu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Epb41l5Gt(XC282)Byg/Epb41l5lulu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
Show

Allelic Composition: Epb41l5lulu/Epb41l5lulu
Genetic Background: involves: C57BL/6J

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0012272 decreased axial mesoderm size "reduced size or deficiency of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [MGI:anna]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031012 Cask / O70589 / Peripheral plasma membrane protein CASK / O14936* / calcium/calmodulin dependent serine protein kinase*  / complex / reaction
 ENSMUSG00000051790 Nlgn2 / Q69ZK9 / Neuroligin-2 / Q8NFZ4*  / complex / reaction
 ENSMUSG00000031302 Nlgn3 / Q8BYM5 / Neuroligin-3 / Q9NZ94*  / reaction / complex
 ENSMUSG00000063887 Nlgn1 / Q99K10 / Neuroligin-1 / Q8N2Q7*  / reaction / complex






 

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