ENSMUSG00000026384


Mus musculus

Features
Gene ID: ENSMUSG00000026384
  
Biological name :Ptpn4
  
Synonyms : Ptpn4 / Q9WU22 / Tyrosine-protein phosphatase non-receptor type 4
  
Possible biological names infered from orthology : P29074 / protein tyrosine phosphatase, non-receptor type 4
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 119652467
Gene end: 119837613
  
Corresponding Affymetrix probe sets: 10357191 (MoGene1.0st)   1421330_at (Mouse Genome 430 2.0 Array)   1434671_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129180
Ensembl peptide - ENSMUSP00000130841
Ensembl peptide - ENSMUSP00000130808
Ensembl peptide - ENSMUSP00000130299
Ensembl peptide - ENSMUSP00000129521
Ensembl peptide - ENSMUSP00000067614
Ensembl peptide - ENSMUSP00000126130
Ensembl peptide - ENSMUSP00000126216
Ensembl peptide - ENSMUSP00000127713
Ensembl peptide - ENSMUSP00000127998
NCBI entrez gene - 19258     See in Manteia.
MGI - MGI:1099792
RefSeq - XM_011247943
RefSeq - NM_019933
RefSeq - XM_006529253
RefSeq - XM_006529254
RefSeq - XM_006529255
RefSeq - XM_006529256
RefSeq Peptide - NP_064317
swissprot - F7CWQ9
swissprot - E9Q210
swissprot - E9QA59
swissprot - Q9WU22
swissprot - E9Q0S8
swissprot - E9PUU9
swissprot - F6PWT7
swissprot - F6U7Q0
swissprot - F6ZWR8
swissprot - F6ZHZ9
Ensembl - ENSMUSG00000026384
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn4aENSDARG00000000631Danio rerio
 ptpn4bENSDARG00000000183Danio rerio
 PTPN4ENSG00000088179Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpn3 / A2ALK8 / protein tyrosine phosphatase, non-receptor type 3 / P26045*ENSMUSG0000003876451
Epb41l1 / band 4.1-like protein 1 isoform d / Q9H4G0* / erythrocyte membrane protein band 4.1 like 1*ENSMUSG0000002762423
Q9WV92 / Epb41l3 / Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed / Q9Y2J2* / erythrocyte membrane protein band 4.1 like 3*ENSMUSG0000002404423
Epb41 / P48193 / erythrocyte membrane protein band 4.1 / P11171*ENSMUSG0000002890622
O70318 / Epb41l2 / Mus musculus erythrocyte membrane protein band 4.1 like 2 (Epb41l2), transcript variant 3, mRNA. / O43491* / erythrocyte membrane protein band 4.1 like 2*ENSMUSG0000001997822
Q8BGS1 / Epb41l5 / Band 4.1-like protein 5 / Q9HCM4* / erythrocyte membrane protein band 4.1 like 5*ENSMUSG0000002638319
P52963 / Epb41l4a / Band 4.1-like protein 4A / Q9HCS5* / erythrocyte membrane protein band 4.1 like 4A*ENSMUSG0000002437618
Q9JMC8 / Epb41l4b / Band 4.1-like protein 4B / Q9H329* / erythrocyte membrane protein band 4.1 like 4B*ENSMUSG0000002843416
Frmd3 / Q8BHD4 / FERM domain-containing protein 3 / A2A2Y4* / FERM domain containing 3*ENSMUSG0000004912215
Frmd5 / Q6P5H6 / FERM domain-containing protein 5 / Q7Z6J6* / FERM domain containing 5*ENSMUSG0000002723814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000299  FERM domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001478  PDZ domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR011993  PH-like domain superfamily
 IPR012151  Protein-tyrosine phosphatase, non-receptor type-3, -4
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: B6.Cg-PhexHyp/J

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: B6.Cg-PhexHyp/J

 MP:0002807 abnormal eye blink conditioning behavior "defects in the ability of an animal to learn to blink in anticipation of an aversive stimulus (e.g., an airpuff to the eyelid) following repeated pairings with a neutral stimulus (e.g., a tone); such learning is only adaptive if the animal is able to learn the precise timing between the conditioned and unconditioned stimuli " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: PhexHyp/Phex+
Genetic Background: B6.Cg-PhexHyp/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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