ENSG00000088179


Homo sapiens

Features
Gene ID: ENSG00000088179
  
Biological name :PTPN4
  
Synonyms : P29074 / protein tyrosine phosphatase, non-receptor type 4 / PTPN4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q14.2
Gene start: 119759631
Gene end: 119983818
  
Corresponding Affymetrix probe sets: 205171_at (Human Genome U133 Plus 2.0 Array)   230230_at (Human Genome U133 Plus 2.0 Array)   232161_x_at (Human Genome U133 Plus 2.0 Array)   236935_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411364
Ensembl peptide - ENSP00000405763
Ensembl peptide - ENSP00000438445
Ensembl peptide - ENSP00000263708
Ensembl peptide - ENSP00000387457
Ensembl peptide - ENSP00000394706
Ensembl peptide - ENSP00000395603
NCBI entrez gene - 5775     See in Manteia.
OMIM - 176878
RefSeq - XM_017004608
RefSeq - XM_017004599
RefSeq - XM_017004600
RefSeq - XM_017004601
RefSeq - XM_017004602
RefSeq - XM_017004603
RefSeq - XM_017004604
RefSeq - XM_017004605
RefSeq - XM_017004606
RefSeq - XM_017004607
RefSeq - NM_002830
RefSeq - XM_011511560
RefSeq - XM_011511562
RefSeq - XM_011511563
RefSeq - XM_017004596
RefSeq - XM_017004597
RefSeq - XM_017004598
RefSeq Peptide - NP_002821
swissprot - J3KQD3
swissprot - J3KQP5
swissprot - J3QT41
swissprot - J3QT59
swissprot - J3QT89
swissprot - A0A024RAE8
swissprot - F5H020
swissprot - P29074
Ensembl - ENSG00000088179
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn4aENSDARG00000000631Danio rerio
 ptpn4bENSDARG00000000183Danio rerio
 Ptpn4ENSMUSG00000026384Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN3 / P26045 / protein tyrosine phosphatase, non-receptor type 3ENSG0000007015952
O43491 / EPB41L2 / erythrocyte membrane protein band 4.1 like 2ENSG0000007981924
Q9Y2J2 / EPB41L3 / erythrocyte membrane protein band 4.1 like 3ENSG0000008239724
Q9H4G0 / EPB41L1 / erythrocyte membrane protein band 4.1 like 1ENSG0000008836723
EPB41 / P11171 / erythrocyte membrane protein band 4.1ENSG0000015902322
Q9H329 / EPB41L4B / erythrocyte membrane protein band 4.1 like 4BENSG0000009520320
Q9HCM4 / EPB41L5 / erythrocyte membrane protein band 4.1 like 5ENSG0000011510919
Q9HCS5 / EPB41L4A / erythrocyte membrane protein band 4.1 like 4AENSG0000012959519
FRMD3 / A2A2Y4 / FERM domain containing 3ENSG0000017215915
FRMD5 / Q7Z6J6 / FERM domain containing 5ENSG0000017187715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000299  FERM domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001478  PDZ domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR011993  PH-like domain superfamily
 IPR012151  Protein-tyrosine phosphatase, non-receptor type-3, -4
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0071345 cellular response to cytokine stimulus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Interleukin-37 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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