ENSG00000171877


Homo sapiens

Features
Gene ID: ENSG00000171877
  
Biological name :FRMD5
  
Synonyms : FERM domain containing 5 / FRMD5 / Q7Z6J6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q15.3
Gene start: 43870761
Gene end: 44195252
  
Corresponding Affymetrix probe sets: 1569470_a_at (Human Genome U133 Plus 2.0 Array)   230831_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452968
Ensembl peptide - ENSP00000404496
Ensembl peptide - ENSP00000454031
Ensembl peptide - ENSP00000490339
Ensembl peptide - ENSP00000479575
Ensembl peptide - ENSP00000384142
Ensembl peptide - ENSP00000392786
Ensembl peptide - ENSP00000399684
Ensembl peptide - ENSP00000401635
Ensembl peptide - ENSP00000403067
NCBI entrez gene - 84978     See in Manteia.
OMIM - 616309
RefSeq - XM_005254730
RefSeq - NM_001286490
RefSeq - NM_001286491
RefSeq - NM_001322949
RefSeq - NM_001322950
RefSeq - NM_001322951
RefSeq - NM_032892
RefSeq Peptide - NP_001309880
RefSeq Peptide - NP_116281
RefSeq Peptide - NP_001309878
RefSeq Peptide - NP_001309879
RefSeq Peptide - NP_001273419
RefSeq Peptide - NP_001273420
swissprot - F8WCI0
swissprot - F8WEJ8
swissprot - H0Y5N1
swissprot - H0YNI9
swissprot - H0YKW6
swissprot - H7C282
swissprot - Q7Z6J6
swissprot - A0A087WVP2
swissprot - B5MC67
swissprot - A0A1B0GV18
Ensembl - ENSG00000171877
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frmd5ENSDARG00000079622Danio rerio
 FRMD5ENSDARG00000075942Danio rerio
 FRMD5ENSGALG00000030858Gallus gallus
 Frmd5ENSMUSG00000027238Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FRMD3 / A2A2Y4 / FERM domain containing 3ENSG0000017215952
Q9H4G0 / EPB41L1 / erythrocyte membrane protein band 4.1 like 1ENSG0000008836730
O43491 / EPB41L2 / erythrocyte membrane protein band 4.1 like 2ENSG0000007981929
EPB41 / P11171 / erythrocyte membrane protein band 4.1ENSG0000015902328
Q9Y2J2 / EPB41L3 / erythrocyte membrane protein band 4.1 like 3ENSG0000008239728
Q9HCM4 / EPB41L5 / erythrocyte membrane protein band 4.1 like 5ENSG0000011510927
Q9HCS5 / EPB41L4A / erythrocyte membrane protein band 4.1 like 4AENSG0000012959526
Q9H329 / EPB41L4B / erythrocyte membrane protein band 4.1 like 4BENSG0000009520326
PTPN4 / P29074 / protein tyrosine phosphatase, non-receptor type 4ENSG0000008817924
PTPN3 / P26045 / protein tyrosine phosphatase, non-receptor type 3ENSG0000007015921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0031032 actomyosin structure organization IBA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:2000146 negative regulation of cell motility IMP
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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