ENSMUSG00000027238


Mus musculus

Features
Gene ID: ENSMUSG00000027238
  
Biological name :Frmd5
  
Synonyms : FERM domain-containing protein 5 / Frmd5 / Q6P5H6
  
Possible biological names infered from orthology : FERM domain containing 5 / Q7Z6J6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 121545529
Gene end: 121807087
  
Corresponding Affymetrix probe sets: 10486875 (MoGene1.0st)   1435956_at (Mouse Genome 430 2.0 Array)   1436243_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118272
Ensembl peptide - ENSMUSP00000118269
Ensembl peptide - ENSMUSP00000120176
Ensembl peptide - ENSMUSP00000148465
Ensembl peptide - ENSMUSP00000122195
Ensembl peptide - ENSMUSP00000106222
Ensembl peptide - ENSMUSP00000106223
Ensembl peptide - ENSMUSP00000113568
Ensembl peptide - ENSMUSP00000115136
Ensembl peptide - ENSMUSP00000116468
NCBI entrez gene - 228564     See in Manteia.
MGI - MGI:2442557
RefSeq - XM_017317742
RefSeq - NM_172673
RefSeq - XM_006499269
RefSeq - XM_011239466
RefSeq - XM_011239469
RefSeq - XM_017317734
RefSeq - XM_017317736
RefSeq - XM_017317738
RefSeq - XM_017317739
RefSeq - XM_017317740
RefSeq Peptide - NP_766261
swissprot - B0R0D5
swissprot - B0R0D4
swissprot - F2Z448
swissprot - F2Z484
swissprot - Q6P5H6
swissprot - F6XM46
swissprot - A2AR56
swissprot - A0A1D5RLQ6
swissprot - F6XLQ6
Ensembl - ENSMUSG00000027238
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 frmd5ENSDARG00000079622Danio rerio
 FRMD5ENSDARG00000075942Danio rerio
 FRMD5ENSGALG00000030858Gallus gallus
 FRMD5ENSG00000171877Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Frmd3 / Q8BHD4 / FERM domain-containing protein 3 / A2A2Y4* / FERM domain containing 3*ENSMUSG0000004912250
Epb41l1 / band 4.1-like protein 1 isoform d / Q9H4G0* / erythrocyte membrane protein band 4.1 like 1*ENSMUSG0000002762431
Q9WV92 / Epb41l3 / Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed / Q9Y2J2* / erythrocyte membrane protein band 4.1 like 3*ENSMUSG0000002404430
Epb41 / P48193 / erythrocyte membrane protein band 4.1 / P11171*ENSMUSG0000002890630
O70318 / Epb41l2 / Mus musculus erythrocyte membrane protein band 4.1 like 2 (Epb41l2), transcript variant 3, mRNA. / O43491* / erythrocyte membrane protein band 4.1 like 2*ENSMUSG0000001997829
Q8BGS1 / Epb41l5 / Band 4.1-like protein 5 / Q9HCM4* / erythrocyte membrane protein band 4.1 like 5*ENSMUSG0000002638329
P52963 / Epb41l4a / Band 4.1-like protein 4A / Q9HCS5* / erythrocyte membrane protein band 4.1 like 4A*ENSMUSG0000002437628
Ptpn4 / Q9WU22 / Tyrosine-protein phosphatase non-receptor type 4 / P29074* / protein tyrosine phosphatase, non-receptor type 4*ENSMUSG0000002638426
Q9JMC8 / Epb41l4b / Band 4.1-like protein 4B / Q9H329* / erythrocyte membrane protein band 4.1 like 4B*ENSMUSG0000002843425
Ptpn3 / A2ALK8 / protein tyrosine phosphatase, non-receptor type 3 / P26045*ENSMUSG0000003876421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030334 regulation of cell migration ISO
 biological_processGO:0031032 actomyosin structure organization IBA
 biological_processGO:0045785 positive regulation of cell adhesion ISO
 biological_processGO:2000146 negative regulation of cell motility ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005912 adherens junction ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Fhl1tm1a(EUCOMM)Wtsi/Fhl1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Fhl1tm1a(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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