ENSMUSG00000038764


Mus musculus

Features
Gene ID: ENSMUSG00000038764
  
Biological name :Ptpn3
  
Synonyms : A2ALK8 / protein tyrosine phosphatase, non-receptor type 3 / Ptpn3
  
Possible biological names infered from orthology : P26045
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B3
Gene start: 57190841
Gene end: 57301837
  
Corresponding Affymetrix probe sets: 10513139 (MoGene1.0st)   10513141 (MoGene1.0st)   10513143 (MoGene1.0st)   10513145 (MoGene1.0st)   10513152 (MoGene1.0st)   10513154 (MoGene1.0st)   10513156 (MoGene1.0st)   10513158 (MoGene1.0st)   10513160 (MoGene1.0st)   10513162 (MoGene1.0st)   10513164 (MoGene1.0st)   10513166 (MoGene1.0st)   1455450_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075063
Ensembl peptide - ENSMUSP00000122490
Ensembl peptide - ENSMUSP00000120111
Ensembl peptide - ENSMUSP00000114805
NCBI entrez gene - 545622     See in Manteia.
MGI - MGI:105307
RefSeq - XM_006538101
RefSeq - XM_006538100
RefSeq - XM_006538097
RefSeq - NM_011207
RefSeq - XM_006538098
RefSeq - XM_006538099
RefSeq Peptide - NP_035337
swissprot - A2ALL1
swissprot - A2ALK8
swissprot - A2ALK9
swissprot - A2ALL0
Ensembl - ENSMUSG00000038764
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn3ENSDARG00000055784Danio rerio
 ENSGALG00000011596Gallus gallus
 PTPN3ENSG00000070159Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptpn4 / Q9WU22 / Tyrosine-protein phosphatase non-receptor type 4 / P29074* / protein tyrosine phosphatase, non-receptor type 4*ENSMUSG0000002638452
Q9WV92 / Epb41l3 / Band 4.1-like protein 3 Band 4.1-like protein 3, N-terminally processed / Q9Y2J2* / erythrocyte membrane protein band 4.1 like 3*ENSMUSG0000002404419
Epb41l1 / band 4.1-like protein 1 isoform d / Q9H4G0* / erythrocyte membrane protein band 4.1 like 1*ENSMUSG0000002762418
O70318 / Epb41l2 / Mus musculus erythrocyte membrane protein band 4.1 like 2 (Epb41l2), transcript variant 3, mRNA. / O43491* / erythrocyte membrane protein band 4.1 like 2*ENSMUSG0000001997818
Epb41 / P48193 / erythrocyte membrane protein band 4.1 / P11171*ENSMUSG0000002890618
Q8BGS1 / Epb41l5 / Band 4.1-like protein 5 / Q9HCM4* / erythrocyte membrane protein band 4.1 like 5*ENSMUSG0000002638315
P52963 / Epb41l4a / Band 4.1-like protein 4A / Q9HCS5* / erythrocyte membrane protein band 4.1 like 4A*ENSMUSG0000002437614
Frmd3 / Q8BHD4 / FERM domain-containing protein 3 / A2A2Y4* / FERM domain containing 3*ENSMUSG0000004912213
Frmd5 / Q6P5H6 / FERM domain-containing protein 5 / Q7Z6J6* / FERM domain containing 5*ENSMUSG0000002723812
Q9JMC8 / Epb41l4b / Band 4.1-like protein 4B / Q9H329* / erythrocyte membrane protein band 4.1 like 4B*ENSMUSG0000002843412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000299  FERM domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001478  PDZ domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR011993  PH-like domain superfamily
 IPR012151  Protein-tyrosine phosphatase, non-receptor type-3, -4
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation ISO
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:0098902 regulation of membrane depolarization during action potential IEA
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tymptm1Mihi/Tymptm1Mihi,Upp1tm1Gp/Upp1tm1Gp
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Ptpn3Gt(RRS555)Byg/Ptpn3Gt(RRS555)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ptpn3tm1Pdk/Ptpn3tm1Pdk
Genetic Background: C57BL/6-Ptpn3tm1Pdk

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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