ENSG00000070159


Homo sapiens

Features
Gene ID: ENSG00000070159
  
Biological name :PTPN3
  
Synonyms : P26045 / protein tyrosine phosphatase, non-receptor type 3 / PTPN3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q31.3
Gene start: 109375466
Gene end: 109498313
  
Corresponding Affymetrix probe sets: 203997_at (Human Genome U133 Plus 2.0 Array)   227944_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262539
Ensembl peptide - ENSP00000363667
Ensembl peptide - ENSP00000395384
Ensembl peptide - ENSP00000416654
NCBI entrez gene - 5774     See in Manteia.
OMIM - 176877
RefSeq - NM_002829
RefSeq - XM_017014957
RefSeq - NM_001145368
RefSeq - NM_001145369
RefSeq - NM_001145370
RefSeq - NM_001145371
RefSeq - NM_001145372
RefSeq - XM_006717201
RefSeq - XM_006717202
RefSeq - XM_006717203
RefSeq - XM_006717204
RefSeq - XM_011518888
RefSeq - XM_011518889
RefSeq - XM_017014955
RefSeq - XM_017014956
RefSeq - XM_006717197
RefSeq - XM_006717199
RefSeq Peptide - NP_001138840
RefSeq Peptide - NP_001138841
RefSeq Peptide - NP_001138842
RefSeq Peptide - NP_001138843
RefSeq Peptide - NP_001138844
RefSeq Peptide - NP_002820
swissprot - P26045
swissprot - J3KN34
Ensembl - ENSG00000070159
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpn3ENSDARG00000055784Danio rerio
 ENSGALG00000011596Gallus gallus
 Ptpn3ENSMUSG00000038764Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPN4 / P29074 / protein tyrosine phosphatase, non-receptor type 4ENSG0000008817953
O43491 / EPB41L2 / erythrocyte membrane protein band 4.1 like 2ENSG0000007981920
Q9Y2J2 / EPB41L3 / erythrocyte membrane protein band 4.1 like 3ENSG0000008239720
Q9H4G0 / EPB41L1 / erythrocyte membrane protein band 4.1 like 1ENSG0000008836719
EPB41 / P11171 / erythrocyte membrane protein band 4.1ENSG0000015902319
Q9HCM4 / EPB41L5 / erythrocyte membrane protein band 4.1 like 5ENSG0000011510916
Q9H329 / EPB41L4B / erythrocyte membrane protein band 4.1 like 4BENSG0000009520316
Q9HCS5 / EPB41L4A / erythrocyte membrane protein band 4.1 like 4AENSG0000012959515
FRMD3 / A2A2Y4 / FERM domain containing 3ENSG0000017215914
FRMD5 / Q7Z6J6 / FERM domain containing 5ENSG0000017187713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000299  FERM domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR001478  PDZ domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR011993  PH-like domain superfamily
 IPR012151  Protein-tyrosine phosphatase, non-receptor type-3, -4
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029071  Ubiquitin-like domain superfamily
 IPR035963  FERM superfamily, second domain
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0045930 negative regulation of mitotic cell cycle IDA
 biological_processGO:0051045 negative regulation of membrane protein ectodomain proteolysis IMP
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:0098902 regulation of membrane depolarization during action potential IDA
 biological_processGO:2000649 regulation of sodium ion transmembrane transporter activity IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017080 sodium channel regulator activity IDA
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
EGFR downregulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000952 Jaundice "Yellow pigmentation of the skin or sclera due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." [HPO:curators]
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 HP:0000989 Pruritus "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus." [HPO:curators]
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 HP:0001945 Fever 
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 HP:0002027 Abdominal pain 
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 HP:0002039 Anorexia 
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 HP:0011985 Acholic stools "Clay colored stools lacking bile pigment." [HPO:probinson]
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0100574 Biliary tract neoplasm "A `neoplasm` (MPATH:218) of the `biliary system` (FMA:79646)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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