ENSG00000115109


Homo sapiens

Features
Gene ID: ENSG00000115109
  
Biological name :EPB41L5
  
Synonyms : EPB41L5 / erythrocyte membrane protein band 4.1 like 5 / Q9HCM4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q14.2
Gene start: 120013005
Gene end: 120179119
  
Corresponding Affymetrix probe sets: 220977_x_at (Human Genome U133 Plus 2.0 Array)   225855_at (Human Genome U133 Plus 2.0 Array)   229292_at (Human Genome U133 Plus 2.0 Array)   230951_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390439
Ensembl peptide - ENSP00000263713
Ensembl peptide - ENSP00000329687
Ensembl peptide - ENSP00000393722
Ensembl peptide - ENSP00000393856
NCBI entrez gene - 57669     See in Manteia.
OMIM - 611730
RefSeq - XM_017004568
RefSeq - NM_001184937
RefSeq - NM_001184938
RefSeq - NM_001184939
RefSeq - NM_001330310
RefSeq - NM_020909
RefSeq - XM_006712651
RefSeq - XM_006712652
RefSeq - XM_006712653
RefSeq - XM_011511529
RefSeq - XM_017004567
RefSeq Peptide - NP_001171866
RefSeq Peptide - NP_001171867
RefSeq Peptide - NP_001171868
RefSeq Peptide - NP_001317239
RefSeq Peptide - NP_065960
swissprot - Q9HCM4
Ensembl - ENSG00000115109
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epb41l5ENSDARG00000032324Danio rerio
 EPB41L5ENSGALG00000011605Gallus gallus
 Q8BGS1ENSMUSG00000026383Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H329 / EPB41L4B / erythrocyte membrane protein band 4.1 like 4BENSG0000009520349
O43491 / EPB41L2 / erythrocyte membrane protein band 4.1 like 2ENSG0000007981928
Q9Y2J2 / EPB41L3 / erythrocyte membrane protein band 4.1 like 3ENSG0000008239727
Q9H4G0 / EPB41L1 / erythrocyte membrane protein band 4.1 like 1ENSG0000008836726
EPB41 / P11171 / erythrocyte membrane protein band 4.1ENSG0000015902326
Q9HCS5 / EPB41L4A / erythrocyte membrane protein band 4.1 like 4AENSG0000012959525
PTPN4 / P29074 / protein tyrosine phosphatase, non-receptor type 4ENSG0000008817925
FRMD3 / A2A2Y4 / FERM domain containing 3ENSG0000017215922
FRMD5 / Q7Z6J6 / FERM domain containing 5ENSG0000017187721
PTPN3 / P26045 / protein tyrosine phosphatase, non-receptor type 3ENSG0000007015920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000798  Ezrin/radixin/moesin-like
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR014847  FERM adjacent (FA)
 IPR018979  FERM, N-terminal
 IPR018980  FERM, C-terminal PH-like domain
 IPR019747  FERM conserved site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR030694  Band 4.1-like protein 5
 IPR035963  FERM superfamily, second domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000904 cell morphogenesis involved in differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001839 neural plate morphogenesis IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0003382 epithelial cell morphogenesis IEA
 biological_processGO:0003383 apical constriction IEA
 biological_processGO:0006931 substrate-dependent cell migration, cell attachment to substrate IEA
 biological_processGO:0007398 ectoderm development IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0007509 mesoderm migration involved in gastrulation IEA
 biological_processGO:0009826 unidimensional cell growth IEA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0022408 negative regulation of cell-cell adhesion IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031032 actomyosin structure organization IBA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032525 somite rostral/caudal axis specification IEA
 biological_processGO:0048318 axial mesoderm development IEA
 biological_processGO:0048319 axial mesoderm morphogenesis IEA
 biological_processGO:0048339 paraxial mesoderm development IEA
 biological_processGO:0048617 embryonic foregut morphogenesis IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0070201 regulation of establishment of protein localization IEA
 biological_processGO:0070986 left/right axis specification IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IBA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton IBA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Neurexins and neuroligins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000147044 CASK / O14936 / calcium/calmodulin dependent serine protein kinase  / reaction / complex






 

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